Momentum transfer Monte Carlo model for the simulation of laser speckle contrast imaging
(Conference Presentation)

Caitlin Regan; Carole K Hayakawa; Bernard Choi

doi:10.1117/12.2212209

26 April 2016 Momentum transfer Monte Carlo model for the simulation of laser speckle contrast imaging (Conference Presentation)

Caitlin Regan, Carole K Hayakawa, Bernard Choi

Author Affiliations +

Proceedings Volume 9707, Dynamics and Fluctuations in Biomedical Photonics XIII; 970703 (2016) https://doi.org/10.1117/12.2212209
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Laser speckle imaging (LSI) enables measurement of relative blood flow in microvasculature and perfusion in tissues. To determine the impact of tissue optical properties and perfusion dynamics on speckle contrast, we developed a computational simulation of laser speckle contrast imaging. We used a discrete absorption-weighted Monte Carlo simulation to model the transport of light in tissue. We simulated optical excitation of a uniform flat light source and tracked the momentum transfer of photons as they propagated through a simulated tissue geometry. With knowledge of the probability distribution of momentum transfer occurring in various layers of the tissue, we calculated the expected laser speckle contrast arising with coherent excitation using both reflectance and transmission geometries. We simulated light transport in a single homogeneous tissue while independently varying either absorption (.001-100mm^-1), reduced scattering (.1-10mm^-1), or anisotropy (0.05-0.99) over a range of values relevant to blood and commonly imaged tissues. We observed that contrast decreased by 49% with an increase in optical scattering, and observed a 130% increase with absorption (exposure time = 1ms). We also explored how speckle contrast was affected by the depth (0-1mm) and flow speed (0-10mm/s) of a dynamic vascular inclusion. This model of speckle contrast is important to increase our understanding of how parameters such as perfusion dynamics, vessel depth, and tissue optical properties affect laser speckle imaging.

Conference Presentation

Citation Download Citation

Caitlin Regan, Carole K Hayakawa, and Bernard Choi "Momentum transfer Monte Carlo model for the simulation of laser speckle contrast imaging (Conference Presentation)", Proc. SPIE 9707, Dynamics and Fluctuations in Biomedical Photonics XIII, 970703 (26 April 2016); https://doi.org/10.1117/12.2212209

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