The influence of cell penetrating peptide branching on cellular uptake of QDs

Joyce Breger; James Delehanty; Kimihiro Susumu; George Anderson; Markus Muttenhaler; Philip Dawson; Igor Medintz

doi:10.1117/12.2207311

22 April 2016 The influence of cell penetrating peptide branching on cellular uptake of QDs

Joyce Breger, James Delehanty, Kimihiro Susumu, George Anderson, Markus Muttenhaler, Philip Dawson, Igor Medintz

Proceedings Volume 9722, Colloidal Nanoparticles for Biomedical Applications XI; 97220R (2016) https://doi.org/10.1117/12.2207311
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Semiconductor quantum dots (QDs) serve as a valuable platform for understating the intricacies of nanoparticle cellular uptake and fate for the development of theranostics. Developing novel internalization peptides that maximize cellular uptake while minimizing the amount of peptide is important to allow space on the nanoparticle for other cargo (e.g. drugs). We have designed a range of branched, dendritic internalization peptides composed of polyarginine (Arg₉) branches (1 to 16 repeats) attached a dendritic wedge based on the sequence WP9G2H6. By attaching these branched dendritic peptides to QD’s, we can study the influence of branching on cellular uptake as a function of time, ratio, and degree of branching.

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Citation Download Citation

Joyce Breger, James Delehanty, Kimihiro Susumu, George Anderson, Markus Muttenhaler, Philip Dawson, and Igor Medintz "The influence of cell penetrating peptide branching on cellular uptake of QDs", Proc. SPIE 9722, Colloidal Nanoparticles for Biomedical Applications XI, 97220R (22 April 2016); https://doi.org/10.1117/12.2207311

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