The use of ultrashort pulse laser for non-linear photoconversion of a bacterial phytochrome

Sergei G. Sokolovski; Edik Rafailov

doi:10.1117/12.2607274

7 March 2022 The use of ultrashort pulse laser for non-linear photoconversion of a bacterial phytochrome

Sergei G. Sokolovski, Edik Rafailov

Proceedings Volume PC11947, Optogenetics and Optical Manipulation 2022; PC1194703 (2022) https://doi.org/10.1117/12.2607274
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

The development of optogenetic approaches for brain research to a new level of knowledge. In this field, the use of plant photoreceptors phytochromes (Phys) optic transition between states absorbing red light (Pr) and far-red light (Pfr), can expand the spectral range of optogenetics to the near-infrared (NIR) range. NIR wavelengths exhibit higher penetration of soft tissues, whereas for the skull it is very low. Here we review our recent results in using bacterial Phy (BPhy) for brain research where we suggested activating BPhy with a femtosecond laser emitting in the 1 – 1.5 micrometer range. Results revealed that the USP laser was capable of nonlinear Pr transformation to Pfr with the highest efficiency at wavelengths between 1170 and 1280 nm.

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Sergei G. Sokolovski and Edik Rafailov "The use of ultrashort pulse laser for non-linear photoconversion of a bacterial phytochrome", Proc. SPIE PC11947, Optogenetics and Optical Manipulation 2022, PC1194703 (7 March 2022); https://doi.org/10.1117/12.2607274

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KEYWORDS

Pulsed laser operation

Optogenetics

Absorption

Brain

Skull

Resolution enhancement technologies

Soft tissue optics

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