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2 March 2022 Towards Raman subcellular imaging of endothelial dysfunction
Ewelina Matuszyk, Anna Pieczara, Basseem Radwan, Adriana Adamczyk, Malgorzata Baranska
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Proceedings Volume PC11973, Advanced Chemical Microscopy for Life Science and Translational Medicine 2022; PC119730X (2022) https://doi.org/10.1117/12.2608123
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Endothelial dysfunction contributes to the pathophysiology of multiple civilization diseases. Biochemical changes of the dysfunctional endothelium are linked to cellular organelles, including mitochondria, nucleus or lysosomes, so organelle-specific insight is needed for better understanding of endothelial pathobiology. Raman imaging, combining chemical specificity with microscopic resolution, is able to detect biochemical changes at subcellular level. However, the detection of spectroscopic markers associated with specific cell organelles, while desirable, cannot easily be achieved by Raman imaging without labeling. Hence, our work focused on development of Raman reporters that opens a new possibilities in subcellular investigation using labeled Raman microscopy with improved specificity.
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Ewelina Matuszyk, Anna Pieczara, Basseem Radwan, Adriana Adamczyk, and Malgorzata Baranska "Towards Raman subcellular imaging of endothelial dysfunction", Proc. SPIE PC11973, Advanced Chemical Microscopy for Life Science and Translational Medicine 2022, PC119730X (2 March 2022); https://doi.org/10.1117/12.2608123
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KEYWORDS
Raman spectroscopy
Blood vessels
Molecules
Pathophysiology
Physiology
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