3D assembly using optical tweezers and biomolecular linkers

Euan McLeod

doi:10.1117/12.2610874

3 March 2022 3D assembly using optical tweezers and biomolecular linkers

Euan McLeod

Proceedings Volume PC11976, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIX; PC1197609 (2022) https://doi.org/10.1117/12.2610874
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Current 3D fabrication approaches either do not have nanoscale resolution, or are severely limited in terms of materials or structure. Here we present optical positioning and linking (OPAL), which uses optical tweezers and biotin-avidin linkage chemistry to assemble previously infeasible metamaterial and biosensor structures out of building blocks. These building blocks include polystyrene microspheres, gold nanospheres, and silica-gold nanoshells. We present the precision assembly of >440 particles into a 3D structure, as well as the fastest published optical tweezer nanoparticle manipulation speeds. Structures are designed using the coupled dipole method, which is particularly fast for these types of structures.

Conference Presentation

Citation Download Citation

Euan McLeod "3D assembly using optical tweezers and biomolecular linkers", Proc. SPIE PC11976, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIX, PC1197609 (3 March 2022); https://doi.org/10.1117/12.2610874

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