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30 May 2022 Developing multimodal imaging data analysis techniques: understanding the skin biochemistry of discoid lupus erythematosus
Hannah U. Holtkamp, Claude Aguergaray, Michel K. Nieuwoudt, Gus Grey, Federico Marini, Cather Simpson, Paul Jarrett
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Proceedings Volume PC12144, Biomedical Spectroscopy, Microscopy, and Imaging II; PC121440F (2022) https://doi.org/10.1117/12.2621515
Event: SPIE Photonics Europe, 2022, Strasbourg, France
Abstract
Discoid Lupus Erythematosus is chronic autoimmune disease that disproportionately affects parts of the population. Presently, the biochemical events involved in the formation of the disease and elements of the pathophysiology are poorly understood, demonstrating a need for improved analysis. We present the results of our multimodal imaging combining Raman spectroscopy and mass spectrometry and their chemometric analysis and models. We distinguish physiological features and how they differ between healthy and DLE. We show that by fusing the data we are able to build a classification model that can differentiate the two with higher accuracy than either technique alone. The findings from this study can serve as a basis for improved biomedical diagnostics and better informed potential treatment options.
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Hannah U. Holtkamp, Claude Aguergaray, Michel K. Nieuwoudt, Gus Grey, Federico Marini, Cather Simpson, and Paul Jarrett "Developing multimodal imaging data analysis techniques: understanding the skin biochemistry of discoid lupus erythematosus", Proc. SPIE PC12144, Biomedical Spectroscopy, Microscopy, and Imaging II, PC121440F (30 May 2022); https://doi.org/10.1117/12.2621515
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KEYWORDS
Skin
Raman spectroscopy
Biochemistry
Multimodal imaging
Data analysis
Tissues
Biological research
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