Quantification of cerebral microhemorrhages with three-dimensional histology

Danny F. Xie; Christian Crouzet; Chuo Fang; Jihua Liu; Han Liu; Wei Ling Lau; David Cribbs; Mark Fisher; Bernard Choi

doi:10.1117/12.2650417

17 March 2023 Quantification of cerebral microhemorrhages with three-dimensional histology

Danny F. Xie, Christian Crouzet, Chuo Fang, Jihua Liu, Han Liu, Wei Ling Lau, David Cribbs, Mark Fisher, Bernard Choi

Proceedings Volume PC12365, Neural Imaging and Sensing 2023; PC1236506 (2023) https://doi.org/10.1117/12.2650417
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Cerebral microhemorrhages (CMH) are the accumulation of hemosiderin-iron deposits which are associated with cognitive impairments. CMH are suspected to be the result of the deterioration of cerebral microvessels. Despite the clinical significance of CMH, our understanding of CMH formation remains limited. Standard histology for CMH visualization is constrained by thin planar views obtained sparsely throughout brain tissue. This limitation can misrepresent the true size and extent of CMH. Here we incorporate tissue clearing to capture a complete view of CMH and compare it to that of a two-dimensional approach.

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Citation Download Citation

Danny F. Xie, Christian Crouzet, Chuo Fang, Jihua Liu, Han Liu, Wei Ling Lau, David Cribbs, Mark Fisher, and Bernard Choi "Quantification of cerebral microhemorrhages with three-dimensional histology", Proc. SPIE PC12365, Neural Imaging and Sensing 2023, PC1236506 (17 March 2023); https://doi.org/10.1117/12.2650417

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