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17 March 2023 Infrared neural stimulation in human cerebral cortex
Li Pan, An Ping, Anna Wang Roe, Kedi Xu, Junming Zhu, Kenneth E. Schriver
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Proceedings Volume PC12366, Optogenetics and Optical Manipulation 2023; PC123660A (2023) https://doi.org/10.1117/12.2657046
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Brain stimulation using electrical, magnetic, and ultrasound offer different spatiotemporal specificities for treating neurological and neuropsychiatric disorders. Towards developing a precision method of targeting specific functional circuits in humans, we have applied infrared neural stimulation to human cerebral cortex intra-operatively. Brief pulse trains of infrared laser light, applied with a fine fiber optic, excites neural activity at submillimeter scale as assessed by intrinsic signal optical imaging. The response is intensity-dependent, non-damaging below threshhold, and activates local cortical networks similar to that in nonhuman primates (NHP). We suggest INS is a promising tool for precision medicine.
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Li Pan, An Ping, Anna Wang Roe, Kedi Xu, Junming Zhu, and Kenneth E. Schriver "Infrared neural stimulation in human cerebral cortex", Proc. SPIE PC12366, Optogenetics and Optical Manipulation 2023, PC123660A (17 March 2023); https://doi.org/10.1117/12.2657046
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KEYWORDS
Cerebral cortex
Infrared radiation
Brain stimulation
Fiber optics
Infrared lasers
Laser damage threshold
Magnetism
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