Single molecule imaging towards 1-nm resolution Raman microscopy

Apitchaya Sanchai

doi:10.1117/12.2688765

5 October 2023 Single molecule imaging towards 1-nm resolution Raman microscopy

Apitchaya Sanchai

Proceedings Volume PC12654, Enhanced Spectroscopies and Nanoimaging 2023; PC1265416 (2023) https://doi.org/10.1117/12.2688765
Event: SPIE Nanoscience + Engineering, 2023, San Diego, California, United States

Conference Poster

Abstract

We will implement 1 nm resolution microscopy with chemical analysis and single molecule sensitivity by using picosecond lasers to excite stimulated Raman scattering (SRS) and measuring the photon force induced on an atomic force microscopy (AFM) tip. With our pulsed lasers system compared to constant power illumination at the same average power, we can significantly increase the signal level up to 2,000 times more. Additionally, we have created finite element models using ANSYS Multiphysics software to study the optical enhancement as a function of Raman shift, considering air and water environments, and key parameters such as tip radius and materials.

Citation Download Citation

Apitchaya Sanchai "Single molecule imaging towards 1-nm resolution Raman microscopy", Proc. SPIE PC12654, Enhanced Spectroscopies and Nanoimaging 2023, PC1265416 (5 October 2023); https://doi.org/10.1117/12.2688765

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