Distinguishing ectopic placental calcification with multi-parametric ultrasound and photoacoustic imaging

Skye A. Edwards; Ana Correia-Branco; Deeksha Sankepalle; Allison Sweeney; Patrick Solomon; Mary C. Wallingford; Srivalleesha Mallidi

doi:10.1117/12.3003133

13 March 2024 Distinguishing ectopic placental calcification with multi-parametric ultrasound and photoacoustic imaging

Skye A. Edwards, Ana Correia-Branco, Deeksha Sankepalle, Allison Sweeney, Patrick Solomon, Mary C. Wallingford, Srivalleesha Mallidi

Author Affiliations +

Proceedings Volume PC12827, Multiscale Imaging and Spectroscopy V; PC1282707 (2024) https://doi.org/10.1117/12.3003133
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Obstetric risks, associated with pre-eclampsia, such as maternal age and pre-existing conditions are on the rise, along with the risk of ectopic calcification and placental vascular dysfunction. We investigated Slc20a2 mice models through non-invasive commercialized and synergistic ultrasound and photoacoustic imaging, which provide dual-wavelength images and radio frequency data. The increased ectopic placental vascular calcification model exhibits reduced fetal growth and decreased postnatal bone mineral density. Our experiments established a significant difference in both placental function and structural differences between normal and diseased placentas through the provided oxygen saturation and quantitative ultrasound spectral parameters.

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Skye A. Edwards, Ana Correia-Branco, Deeksha Sankepalle, Allison Sweeney, Patrick Solomon, Mary C. Wallingford, and Srivalleesha Mallidi "Distinguishing ectopic placental calcification with multi-parametric ultrasound and photoacoustic imaging", Proc. SPIE PC12827, Multiscale Imaging and Spectroscopy V, PC1282707 (13 March 2024); https://doi.org/10.1117/12.3003133

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