Polarization-sensitive optical coherence tomography (PS-OCT) allows the visualization of biological tissue microstructure by measuring the pathlength difference, amplitude, and polarization of backscattered light. Speckle grains complicate the visualizations due to scattering structures in tissue smaller than the PS-OCT resolution. We developed an angular compounding system to reduce speckle by rotating samples and collecting tomograms at multiple imaging angles, without modifying PS-OCT hardware or optical pathways. Tomograms were acquired, aligned with affine transformations, and averaged. This method successfully reduced the speckle and improved visualization of intensity and birefringence images.
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