Photonics probing of DNA molecular specific spatial structural alterations in cell nuclei due to the probiotic and alcohol effects on colon cancer via a light localization method using confocal imaging

Ishmael Apachigawo; Dhruvil Solanki; Pradeep Shukla; Radhakrishna Rao; Pradhan Prabhakar

doi:10.1117/12.3022739

13 March 2024 Photonics probing of DNA molecular specific spatial structural alterations in cell nuclei due to the probiotic and alcohol effects on colon cancer via a light localization method using confocal imaging

Ishmael Apachigawo, Dhruvil Solanki, Pradeep Shukla, Radhakrishna Rao, Pradhan Prabhakar

Author Affiliations +

Proceedings Volume PC12840, Optical Interactions with Tissue and Cells XXXV; PC1284009 (2024) https://doi.org/10.1117/12.3022739
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

A photonics localization method, called inverse participation ratio (IPR), is adeptly applied to elucidate the effects of probiotics and alcohol on colon cancer by quantifying the DNA molecular-specific spatial structural changes in colon cancer cell nuclei on a colon cancer mouse model via confocal imaging. The IPR light localization technique measures the degree of structural disorder of DNA molecular-specific spatial mass density fluctuations. The nuclear structural alterations in colon cancer cell nuclei have been known to begin at the nano-to-submicron level, which precedes and predicts more prominent microscopic observations later in the disease. The effects of probiotics on alcohol-treated colon cancer are not a well-understood problem. However, probiotics like Lactobacillus have proven effective in enhancing colon cell/tissue functions. The IPR study results show that alcohol treatment enhances colon cancer, and the treatment of probiotics on alcohol-treated colon cancer tries to bring colon cancer less severe to normal. We acknowledge the grant NIH- R21CA260147.

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Ishmael Apachigawo, Dhruvil Solanki, Pradeep Shukla, Radhakrishna Rao, and Pradhan Prabhakar "Photonics probing of DNA molecular specific spatial structural alterations in cell nuclei due to the probiotic and alcohol effects on colon cancer via a light localization method using confocal imaging", Proc. SPIE PC12840, Optical Interactions with Tissue and Cells XXXV, PC1284009 (13 March 2024); https://doi.org/10.1117/12.3022739

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KEYWORDS

Colorectal cancer

Confocal microscopy

Photonics

Molecular photonics

Diseases and disorders

Animal model studies

Colon

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