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13 March 2024 Origin of collagen chiral response in polarimetric second harmonic generation microscopy
Mehdi Alizadeh, Viktoras Mazeika, Danute Bulotiene, Vitalijus Karabanovas, Lukas Kontenis, Virginijus Barzda
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Proceedings Volume PC12847, Multiphoton Microscopy in the Biomedical Sciences XXIV; PC128470O (2024) https://doi.org/10.1117/12.3003060
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
We investigate the chiral response of type I collagen using polarimetric second harmonic generation (SHG) microscopy. By flipping the sample, we observe changes in the sign of the amplitude of the chiral susceptibility ratio (C), while its retardancy phase with respect to the achiral ratio (R) remains unchanged. Our findings suggest that the chiral response of collagen originates from the interaction between electric dipole moments and laser radiation. This study demonstrates the potential of polarimetric SHG microscopy for studying collagen properties and visualizing disease-related alterations.
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Mehdi Alizadeh, Viktoras Mazeika, Danute Bulotiene, Vitalijus Karabanovas, Lukas Kontenis, and Virginijus Barzda "Origin of collagen chiral response in polarimetric second harmonic generation microscopy", Proc. SPIE PC12847, Multiphoton Microscopy in the Biomedical Sciences XXIV, PC128470O (13 March 2024); https://doi.org/10.1117/12.3003060
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KEYWORDS
Collagen
Second harmonic generation
Polarimetry
Microscopy
Laser radiation
Dichroic materials
Diseases and disorders
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