Extra-receptor signaling: how the lipid bilayer transduces neurotransmitter signals

Sudipta Maiti

doi:10.1117/12.3010037

10 April 2024 Extra-receptor signaling: how the lipid bilayer transduces neurotransmitter signals

Sudipta Maiti

Proceedings Volume PC12847, Multiphoton Microscopy in the Biomedical Sciences XXIV; PC128470Z (2024) https://doi.org/10.1117/12.3010037
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Chemical signaling is essential to information processing in the brain. The key events of this process in the mammalian brain are the exocytotic release of signaling molecules by one cell and its binding to a receptor molecule on the recipient cell, which then transduces the chemical message. Here we ask: if we take the receptors away, can there still be signaling? We find that the lipid bilayer responds to some signaling molecules, such as serotonin, and changes its order and mechanical properties. We then combine non-epifluorescence multiphoton UV with spectral confocal microscopy and show that these changes modulate membrane-mediated processes such as exo- and endocytosis. It also affects the functioning of non-cognate receptor proteins in the membrane. Nature appears to have optimized the membrane compositions of different organelles to tune them for neurotransmitter interactions. In summary, the lipid bilayer membrane can itself be a receptor for many signaling molecules. Potentially, our findings pave the way for a major new class of membrane-active but receptor-silent pharmacological agents that can affect biological function.

Conference Presentation

Citation Download Citation

Sudipta Maiti "Extra-receptor signaling: how the lipid bilayer transduces neurotransmitter signals", Proc. SPIE PC12847, Multiphoton Microscopy in the Biomedical Sciences XXIV, PC128470Z (10 April 2024); https://doi.org/10.1117/12.3010037

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