Imaging colloidal gold nanorod and microparticle agglutination with lens-free holographic microscopy for biomolecule sensing

Colin J. Potter; Euan McLeod

doi:10.1117/12.3003197

13 March 2024 Imaging colloidal gold nanorod and microparticle agglutination with lens-free holographic microscopy for biomolecule sensing

Colin J. Potter, Euan McLeod

Author Affiliations +

Proceedings Volume PC12850, Optical Diagnostics and Sensing XXIV: Toward Point-of-Care Diagnostics; PC1285006 (2024) https://doi.org/10.1117/12.3003197
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Healthcare disparities revealed during the COVID-19 pandemic must be addressed. A simple way to enable care to reach remote or low-resource communities is through inexpensive, rapid, sensitive, and portable biosensors. Here, we discuss work on the development and testing of a lens-free holographic microscopy (LFHM) and agglutination assay-based biosensor capable of rapid and sensitive point-of-care detection of SARS-CoV-2 virus. Additionally, we discuss recent efforts to further improve this sensor by using colloidal gold nanorods and machine learning approaches.

Conference Presentation

Citation Download Citation

Colin J. Potter and Euan McLeod "Imaging colloidal gold nanorod and microparticle agglutination with lens-free holographic microscopy for biomolecule sensing", Proc. SPIE PC12850, Optical Diagnostics and Sensing XXIV: Toward Point-of-Care Diagnostics, PC1285006 (13 March 2024); https://doi.org/10.1117/12.3003197

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