Eutectic gallium-indium alloy-based liquid metal nanoparticles for biomedical imaging and photodynamic therapy

Marvin Xavierselvan; Sumeyra Gokalp; Sabrina S. Hafiz; Michelle Foster; Srivalleesha Mallidi

doi:10.1117/12.3003286

13 March 2024 Eutectic gallium-indium alloy-based liquid metal nanoparticles for biomedical imaging and photodynamic therapy

Marvin Xavierselvan, Sumeyra Gokalp, Sabrina S. Hafiz, Michelle Foster, Srivalleesha Mallidi

Author Affiliations +

Proceedings Volume PC12859, Colloidal Nanoparticles for Biomedical Applications XIX; PC1285906 (2024) https://doi.org/10.1117/12.3003286
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Liquid metal nanoparticles, particularly Eutectic Gallium Indium (EGaIn), hold great potential in medical applications such as biosensors, bioelectrodes, cancer treatment, and medical imaging. This study focuses on the synthesis of EGaIn nanoparticles using sonication without harsh chemicals. The nanoparticles are surface functionalized with hyaluronan and the photosensitizer benzoporphyrin derivative (BPD) for photodynamic therapy. EGaIn nanoparticles exhibit stability, good biocompatibility, and high optical absorption for photoacoustic imaging. The singlet oxygen generation of EGaPs is compared with free BPD under physiological conditions. Additionally, in vitro and in vivo investigations confirm the photodynamic efficacy of EGaPs, making them versatile nanoparticles for targeting, imaging, drug delivery, and photodynamic therapy

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Citation Download Citation

Marvin Xavierselvan, Sumeyra Gokalp, Sabrina S. Hafiz, Michelle Foster, and Srivalleesha Mallidi "Eutectic gallium-indium alloy-based liquid metal nanoparticles for biomedical imaging and photodynamic therapy", Proc. SPIE PC12859, Colloidal Nanoparticles for Biomedical Applications XIX, PC1285906 (13 March 2024); https://doi.org/10.1117/12.3003286

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