Electrical stimulation has emerged as a therapeutic approach for accelerating the healing of wound. Piezoelectric materials, characterized by their ability to generate electrical potential differences when applied to mechanical stress, have shown great potential in this regard. Poly(vinylidene fluoride-trifluoroethylene) (PVDF-TrFE), an important engineering piezoelectric polymer, exhibits biocompatibility, high piezoelectric properties, and chemical stability. Electrospinning is a promising way for fabricating P(VDF-TrFE) fibers with enhanced electroactive β-phase contents of P(VDF-TrFE) through in-situ poling effects and mechanical stretching.In this work, we tailor P(VDF-TrFE) fiber porous structures to mimic the structure of extracellular matrix (ECM) and furthermore, enhance electrical stimulation for accelerating wound healing. Moreover, the wound healing process is often hindered by bacterial infections. To address this concern, our strategy is to incorporate antibacterial zinc oxide (ZnO) nanoparticles into PVDF-TrFE electrospun fibers. We conduct in vitro wound healing assays and evaluate the antibacterial properties of our multifunctional piezoelectric fibers..
|