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19 June 2024 Novel mechanical contrast in optical coherence elastography based on tissue heterogeneity
Brendan F. Kennedy, Jiayue Li, Ken Y. Foo, Rowan W. Sanderson, Renate Zilkens, Anmol Rijhumal, Mireille Hardie, Christobel M. Saunders
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Proceedings Volume PC13010, Tissue Optics and Photonics III; PC130100G (2024) https://doi.org/10.1117/12.3029505
Event: SPIE Photonics Europe, 2024, Strasbourg, France
Abstract
Optical coherence elastography (OCE) provides mechanical contrast on the micro-scale and has shown promise in a number of clinical applications. In the majority of OCE methods, local homogeneity is inherently assumed in the mechanical models, which results in low accuracy in complex tissues. Here, we present a novel compression OCE method that exploits tissue heterogeneity to generate mechanical contrast in human breast tissue by mapping the full strain tensor. We used the strain tensor to map mechanical parameters such as Euler angle of principal compression. We also demonstrate a new form of quantitative OCE by mapping local Poisson’s ratio.
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Brendan F. Kennedy, Jiayue Li, Ken Y. Foo, Rowan W. Sanderson, Renate Zilkens, Anmol Rijhumal, Mireille Hardie, and Christobel M. Saunders "Novel mechanical contrast in optical coherence elastography based on tissue heterogeneity", Proc. SPIE PC13010, Tissue Optics and Photonics III, PC130100G (19 June 2024); https://doi.org/10.1117/12.3029505
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KEYWORDS
Tissues
Elastography
Optical coherence
Nervous system
Breast
Deformation
3D image processing
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