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1 January 2008 Diagnosis of degenerative lesions of supraspinatus rotator cuff tendons by Fourier transform-Raman spectroscopy
Sergio Godoy Penteado, Bianca Palma Fogazza, Carolina da Silva Carvalho, Emilia Angela Loschiavo Arisawa, Mario Augusto da Silva Martins, Airton Abr Martin, Herculano da Martinho
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Journal of Biomedical Optics, Vol. 13, Issue 1, 014018 (January 2008). https://doi.org/10.1117/1.2841017
Abstract
The Fourier transform (FT)-Raman spectroscopy technique is used to assess the biochemical alterations that occur in the degenerative process of the rotator cuff supraspinatus tendon. The main alterations observed occur in the glycine, proline, hydroxyproline, cysteine, cistine, phenylalanine, tyrosine, collagen I and III, nucleic acid, lipids, glycosaminoglycans, and metalloproteinases bands. An increasing intensity for these bands is found in degenerated tendons, a finding well correlated with hyaline state and cellular activity. Statistical analysis (principal components analysis and clustering) shows a clear separation of the spectra into nonhyalinized and hyalinized clusters, which enables the construction of a binary diagnosis model based on logistic regression. Best diagnosis provided a sensitivity of 66.0% and a specificity of 74.7% with 79.6% concordant pairs. The discriminating power of the diagnostic test is assessed by computing the area under the receiving-operator characteristic curve (AUC), which indicates good accuracy (AUC=0.81). In principle, these results indicate that Raman spectroscopy can be used as an auxiliary aid to improve shoulder tendon surgery quality by guiding anchoring onto more healthy (nonhyaline) pieces of tendons. This should contribute to a decrease in the current high rerupture rate (13 to 68%) for this procedure.
©(2008) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Sergio Godoy Penteado, Bianca Palma Fogazza, Carolina da Silva Carvalho, Emilia Angela Loschiavo Arisawa, Mario Augusto da Silva Martins, Airton Abr Martin, and Herculano da Martinho "Diagnosis of degenerative lesions of supraspinatus rotator cuff tendons by Fourier transform-Raman spectroscopy," Journal of Biomedical Optics 13(1), 014018 (1 January 2008). https://doi.org/10.1117/1.2841017
Published: 1 January 2008
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Cited by 19 scholarly publications.
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KEYWORDS
Collagen
Raman spectroscopy
Lawrencium
Optical fibers
Surgery
Tissues
Spectroscopy
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