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1 July 2010 Study of back-scattering microspectrum for stomach cells at single-cell scale
Cheng Wang, Xudong Guo, Baoying Fang, Chengli Song
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Journal of Biomedical Optics, Vol. 15, Issue 4, 040505 (July 2010). https://doi.org/10.1117/1.3469782
Abstract
A fiber confocal backscattering (FCBS) spectrometer is developed based on fiber confocal microscopy and light scattering theory. The FCBS spectrometer can provide imaging and spectral information simultaneously at the cellular scale. Normal stomach epithelial cell line GES-1 and cancerous cell line NCI-N87 are measured and their spectral results show that backscattering intensity from NCI-N87 cells is stronger than that from GES-1 cells in 500 to 800 nm, and the GES-1 cells scattering spectra show regular intensity changes, while the NCI-N87 cells do not. The experiments prove that the FCBS spectrometer is able to distinguish cancerous cells from normal stomach cells at the cellular level. The spectrometer could be further developed into a noninvasive optical technology for early cancer detection.
©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Cheng Wang, Xudong Guo, Baoying Fang, and Chengli Song "Study of back-scattering microspectrum for stomach cells at single-cell scale," Journal of Biomedical Optics 15(4), 040505 (1 July 2010). https://doi.org/10.1117/1.3469782
Published: 1 July 2010
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Cited by 5 scholarly publications.
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KEYWORDS
Spectroscopy
Light scattering
Backscatter
Scattering
Confocal microscopy
Stomach
Cancer
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