Simultaneous in vivo imaging of melanin and lipofuscin in the retina with photoacoustic ophthalmoscopy and autofluorescence imaging

Xiangyang Zhang; Carmen A. Puliafito M.D.; Shuliang Jiao; Hao F. Zhang

doi:10.1117/1.3606569

1 August 2011 Simultaneous in vivo imaging of melanin and lipofuscin in the retina with photoacoustic ophthalmoscopy and autofluorescence imaging

Xiangyang Zhang, Carmen A. Puliafito M.D., Shuliang Jiao, Hao F. Zhang

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Journal of Biomedical Optics, Vol. 16, Issue 8, 080504 (August 2011). https://doi.org/10.1117/1.3606569

Abstract

We combined photoacoustic ophthalmoscopy (PAOM) with autofluorescence imaging for simultaneous in vivo imaging of dual molecular contrasts in the retina using a single light source. The dual molecular contrasts come from melanin and lipofuscin in the retinal pigment epithelium (RPE). Melanin and lipofuscin are two types of pigments and are believed to play opposite roles (protective versus exacerbate) in the RPE in the aging process. We have successfully imaged the retina of pigmented and albino rats at different ages. The experimental results showed that multimodal PAOM system can be a potentially powerful tool in the study of age-related degenerative retinal diseases.

©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Xiangyang Zhang, Carmen A. Puliafito M.D., Shuliang Jiao, and Hao F. Zhang "Simultaneous in vivo imaging of melanin and lipofuscin in the retina with photoacoustic ophthalmoscopy and autofluorescence imaging," Journal of Biomedical Optics 16(8), 080504 (1 August 2011). https://doi.org/10.1117/1.3606569

Published: 1 August 2011

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