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7 February 2012 Preliminary evaluation of optical glucose sensing in red cell concentrations using near-infrared diffuse-reflectance spectroscopy
Yusuke Suzuki, Katsuhiko Maruo, Alice Zhang, Kazushige Shimogaki, Hideto Ogawa, Fumiya Hirayama
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Journal of Biomedical Optics, Vol. 17, Issue 1, 017004 (February 2012). https://doi.org/10.1117/1.JBO.17.1.017004
Abstract
Bacterial contamination of blood products is one of the most frequent infectious complications of transfusion. Since glucose levels in blood supplies decrease as bacteria proliferate, it should be possible to detect the presence of bacterial contamination by measuring the glucose concentrations in the blood components. Hence this study is aimed to serve as a preliminary study for the nondestructive measurement of glucose level in transfusion blood. The glucose concentrations in red blood cell (RBC) samples were predicted using near-infrared diffuse-reflectance spectroscopy in the 1350 to 1850 nm wavelength region. Furthermore, the effects of donor, hematocrit level, and temperature variations among the RBC samples were observed. Results showed that the prediction performance of a dataset which contained samples that differed in all three parameters had a standard error of 29.3 mg/dL. Multiplicative scatter correction (MSC) preprocessing method was also found to be effective in minimizing the variations in scattering patterns created by various sample properties. The results suggest that the diffuse-reflectance spectroscopy may provide another avenue for the detection of bacterial contamination in red cell concentrations (RCC) products.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2012/$25.00 © 2012 SPIE
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Yusuke Suzuki, Katsuhiko Maruo, Alice Zhang, Kazushige Shimogaki, Hideto Ogawa, and Fumiya Hirayama "Preliminary evaluation of optical glucose sensing in red cell concentrations using near-infrared diffuse-reflectance spectroscopy," Journal of Biomedical Optics 17(1), 017004 (7 February 2012). https://doi.org/10.1117/1.JBO.17.1.017004
Published: 7 February 2012
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Cited by 7 scholarly publications and 1 patent.
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KEYWORDS
Glucose
Magnesium
Blood
Spectroscopy
Near infrared spectroscopy
Optical fibers
Contamination
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