Time-reversed ultrasonically encoded optical focusing in biological tissue

Puxiang Lai; Xiao Xu; Honglin Liu; Lihong V. Wang

doi:10.1117/1.JBO.17.3.030506

8 March 2012 Time-reversed ultrasonically encoded optical focusing in biological tissue

Puxiang Lai, Xiao Xu, Honglin Liu, Lihong V. Wang

Author Affiliations +

Journal of Biomedical Optics, Vol. 17, Issue 3, 030506 (March 2012). https://doi.org/10.1117/1.JBO.17.3.030506

Abstract

We report an experimental investigation of time-reversed ultrasonically encoded optical focusing in biological tissue. This technology combines the concepts of optical phase conjugation and ultrasound modulation of diffused coherent light. The ultrasonically encoded (or tagged) diffused light from a tissue sample is collected in reflection mode and interferes with a reference light in a photorefractive crystal (used as a phase conjugation mirror) to form a hologram. Then a time-reversed copy of the tagged light is generated and traces back the original trajectories to the ultrasonic focus inside the tissue sample. With our current setup, we can achieve a maximum penetration depth of 5 mm in a chicken breast sample and image optical contrasts within a tissue sample with a spatial resolution approximately equaling 1/√2 of the ultrasound focal diameter.

Citation Download Citation

Puxiang Lai, Xiao Xu, Honglin Liu, and Lihong V. Wang "Time-reversed ultrasonically encoded optical focusing in biological tissue," Journal of Biomedical Optics 17(3), 030506 (8 March 2012). https://doi.org/10.1117/1.JBO.17.3.030506

Published: 8 March 2012

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

CITATIONS

Cited by 33 scholarly publications.

Explore citations on Lens.org

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Tissue optics

Ultrasonography

Biomedical optics

Tissues

Holograms

Photons

Beam splitters

Show All Keywords

RELATED CONTENT

Imaging speckle decorrelation effect with combined acousto optical imaging with...
Proceedings of SPIE (December 09 2021)

Fundamental study for scattering suppression in biological tissue using digital...
Proceedings of SPIE (April 18 2017)

Curriculum in biomedical optics and laser-tissue interactions
Proceedings of SPIE (October 06 2003)

Focusing light in deep tissue with time reversed ultrasound microbubble...
Proceedings of SPIE (January 01 1900)

Optomechatronic prototype based on digital holographic interferometry aimed to the...
Proceedings of SPIE (November 02 2011)

Photorefractive acousto optic imaging in the therapeutic window
Proceedings of SPIE (February 17 2011)

Subscribe to Digital Library

Receive Erratum Email Alert

Show All Keywords

Keywords/Phrases

Search In:

Publication Years