Monitoring photodynamic therapy with photoacoustic microscopy

Peng Shao; David W. Chapman; Ronald B. Moore; Roger J. Zemp

doi:10.1117/1.JBO.20.10.106012

28 October 2015 Monitoring photodynamic therapy with photoacoustic microscopy

Peng Shao, David W. Chapman, Ronald B. Moore, Roger J. Zemp

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Journal of Biomedical Optics, Vol. 20, Issue 10, 106012 (October 2015). https://doi.org/10.1117/1.JBO.20.10.106012

Abstract

We present our work on examining the feasibility of monitoring photodynamic therapy (PDT)-induced vasculature change with acoustic-resolution photoacoustic microscopy (PAM). Verteporfin, an FDA-approved photosensitizer for clinical PDT, was utilized. With a 60-μm-resolution PAM system, we demonstrated the capability of PAM to monitor PDT-induced vasculature variations in a chick chorioallantoic membrane model with topical application and in a rat ear with intravenous injection of the photosensitizer. We also showed oxygen saturation change in target blood vessels due to PDT. Success of the present approach may potentially lead to the application of PAM imaging in evaluating PDT efficacy, guiding treatment, and predicting responders from nonresponders.

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Peng Shao, David W. Chapman, Ronald B. Moore, and Roger J. Zemp "Monitoring photodynamic therapy with photoacoustic microscopy," Journal of Biomedical Optics 20(10), 106012 (28 October 2015). https://doi.org/10.1117/1.JBO.20.10.106012

Published: 28 October 2015

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