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6 November 2015 Holographic analysis on deformation and restoration of malaria-infected red blood cells by antimalarial drug
Hyeokjun Byeon, Young-Ran Ha, Sang-Joon Lee
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Journal of Biomedical Optics, Vol. 20, Issue 11, 115003 (November 2015). https://doi.org/10.1117/1.JBO.20.11.115003
Abstract
Malaria parasites induce morphological, biochemical, and mechanical changes in red blood cells (RBCs). Mechanical variations are closely related to the deformability of individual RBCs. The deformation of various RBCs, including healthy and malaria-infected RBCs (iRBCs), can be directly observed through quantitative phase imaging (QPI). The effects of chloroquine treatment on the mechanical property variation of iRBCs were investigated using time-resolved holographic QPI of single live cells on a millisecond time scale. The deformabilities of healthy RBCs, iRBCs, and drug-treated iRBCs were compared, and the effect of chloroquine on iRBC restoration was experimentally examined. The present results are beneficial to elucidate the dynamic characteristics of iRBCs and the effect of the antimalarial drug on iRBCs.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2015/$25.00 © 2015 SPIE
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Hyeokjun Byeon, Young-Ran Ha, and Sang-Joon Lee "Holographic analysis on deformation and restoration of malaria-infected red blood cells by antimalarial drug," Journal of Biomedical Optics 20(11), 115003 (6 November 2015). https://doi.org/10.1117/1.JBO.20.11.115003
Published: 6 November 2015
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Cited by 7 scholarly publications.
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KEYWORDS
Blood
Holography
Proteins
Microscopy
Biological research
Diffraction
Holograms
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