Decoupled fluorescence Monte Carlo model for direct computation of fluorescence in turbid media

Zhaoyang Luo; Yong Deng; Kan Wang; Lichao Lian; Xiaoquan Yang; Qingming Luo

doi:10.1117/1.JBO.20.2.025002

3 February 2015 Decoupled fluorescence Monte Carlo model for direct computation of fluorescence in turbid media

Zhaoyang Luo, Yong Deng, Kan Wang, Lichao Lian, Xiaoquan Yang, Qingming Luo

Author Affiliations +

Journal of Biomedical Optics, Vol. 20, Issue 2, 025002 (February 2015). https://doi.org/10.1117/1.JBO.20.2.025002

Abstract

We present a decoupled fluorescence Monte Carlo (dfMC) model for the direct computation of the fluorescence in turbid media. By decoupling the excitation-to-emission conversion and transport process of the fluorescence from the path probability density function and associating the corresponding parameters involving the fluorescence process with the weight function, the dfMC model employs the path histories of the excitation photons and the corresponding new weight function to directly calculate the fluorescence. We verify the model’s accuracy using phantom experiments and compare it with that of the perturbation fluorescence Monte Carlo model. The results indicate that the model is accurate for the direct fluorescence calculation and, thus, has great potential for application in fluorescence-based in vivo tomography.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Zhaoyang Luo, Yong Deng, Kan Wang, Lichao Lian, Xiaoquan Yang, and Qingming Luo "Decoupled fluorescence Monte Carlo model for direct computation of fluorescence in turbid media," Journal of Biomedical Optics 20(2), 025002 (3 February 2015). https://doi.org/10.1117/1.JBO.20.2.025002

Published: 3 February 2015

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Cited by 4 scholarly publications.

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KEYWORDS

Luminescence

Photons

Monte Carlo methods

Scattering

Atrial fibrillation

Absorption

Sensors

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