Diagnose human colonic tissues by terahertz near-field imaging

Hua Chen; Shi Hua Ma; Xiumei Wu; Wenxing Yang; Tian Zhao

doi:10.1117/1.JBO.20.3.036017

27 March 2015 Diagnose human colonic tissues by terahertz near-field imaging

Hua Chen, Shi Hua Ma, Xiumei Wu, Wenxing Yang, Tian Zhao

Author Affiliations +

Journal of Biomedical Optics, Vol. 20, Issue 3, 036017 (March 2015). https://doi.org/10.1117/1.JBO.20.3.036017

Abstract

Based on a terahertz (THz) pipe-based near-field imaging system, we demonstrate the capability of THz imaging to diagnose freshly surgically excised human colonic tissues. Through THz near-field scanning the absorbance of the colonic tissues, the acquired images can clearly distinguish cancerous tissues from healthy tissues fast and automatically without pathological hematoxylin and eosin stain diagnosis. A statistical study on 58 specimens (20 healthy tissues and 38 tissues with tumor) from 31 patients (mean age: 59 years; range: 46 to 79 years) shows that the corresponding diagnostic sensitivity and specificity on colonic tissues are both 100%. Due to its capability to perform quantitative analysis, our study indicates the potential of the THz pipe-based near-field imaging for future automation on human tumor pathological examinations.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Hua Chen, Shi Hua Ma, Xiumei Wu, Wenxing Yang, and Tian Zhao "Diagnose human colonic tissues by terahertz near-field imaging," Journal of Biomedical Optics 20(3), 036017 (27 March 2015). https://doi.org/10.1117/1.JBO.20.3.036017

Published: 27 March 2015

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KEYWORDS

Tissues

Terahertz radiation

Near field

Tumors

Absorbance

Diagnostics

Imaging systems

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