Reproducibility of parameters of postocclusive reactive hyperemia measured by diffuse optical tomography

Ernesto E. Vidal-Rosas; Stephen A. Billings; Timothy J. Chico M.D.; Daniel Coca

doi:10.1117/1.JBO.21.6.066012

15 June 2016 Reproducibility of parameters of postocclusive reactive hyperemia measured by diffuse optical tomography

Ernesto E. Vidal-Rosas, Stephen A. Billings, Timothy J. Chico M.D., Daniel Coca

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Journal of Biomedical Optics, Vol. 21, Issue 6, 066012 (June 2016). https://doi.org/10.1117/1.JBO.21.6.066012

Abstract

The application of near-infrared spectroscopy (NIRS) to assess microvascular function has shown promising results. An important limitation when using a single source-detector pair, however, is the lack of depth sensitivity. Diffuse optical tomography (DOT) overcomes this limitation using an array of sources and detectors that allow the reconstruction of volumetric hemodynamic changes. This study compares the key parameters of postocclusive reactive hyperemia measured in the forearm using standard NIRS and DOT. We show that while the mean parameter values are similar for the two techniques, DOT achieves much better reproducibility, as measured by the intraclass correlation coefficient (ICC). We show that DOT achieves high reproducibility for muscle oxygen consumption (ICC: 0.99), time to maximal HbO₂ (ICC: 0.94), maximal HbO₂ (ICC: 0.99), and time to maximal HbT (ICC: 0.99). Absolute reproducibility as measured by the standard error of measurement is consistently smaller and close to zero (ideal value) across all parameters measured by DOT compared to NIRS. We conclude that DOT provides a more robust characterization of the reactive hyperemic response and show how the availability of volumetric hemodynamic changes allows the identification of areas of temporal consistency, which could help characterize more precisely the microvasculature.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Ernesto E. Vidal-Rosas, Stephen A. Billings, Timothy J. Chico M.D., and Daniel Coca "Reproducibility of parameters of postocclusive reactive hyperemia measured by diffuse optical tomography," Journal of Biomedical Optics 21(6), 066012 (15 June 2016). https://doi.org/10.1117/1.JBO.21.6.066012

Published: 15 June 2016

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