Automated three-dimensional registration and volume rebuilding for wide-field angiographic and structural optical coherence tomography

Pengxiao Zang; Gangjun Liu; Miao Zhang; Jie Wang; Thomas S. Hwang; David J. Wilson; David Huang; Dengwang Li; Yali Jia

doi:10.1117/1.JBO.22.2.026001

1 February 2017 Automated three-dimensional registration and volume rebuilding for wide-field angiographic and structural optical coherence tomography

Pengxiao Zang, Gangjun Liu, Miao Zhang, Jie Wang, Thomas S. Hwang, David J. Wilson, David Huang, Dengwang Li, Yali Jia

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Journal of Biomedical Optics, Vol. 22, Issue 2, 026001 (February 2017). https://doi.org/10.1117/1.JBO.22.2.026001

Abstract

We propose a three-dimensional (3-D) registration method to correct motion artifacts and construct the volume structure for angiographic and structural optical coherence tomography (OCT). This algorithm is particularly suitable for the nonorthogonal wide-field OCT scan acquired by a ultrahigh-speed swept-source system (>200 kHz A-scan rate). First, the transverse motion artifacts are corrected by the between-frame registration based on en face OCT angiography (OCTA). After A-scan transverse translation between B-frames, the axial motions are corrected based on the rebuilt boundary of inner limiting membrane. Finally, a within-frame registration is performed for local optimization based on cross-sectional OCTA. We evaluated this algorithm on retinal volumes of six normal subjects. The results showed significantly improved retinal smoothness in 3-D-registered structural OCT and image contrast on en face OCTA.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Pengxiao Zang, Gangjun Liu, Miao Zhang, Jie Wang, Thomas S. Hwang, David J. Wilson, David Huang, Dengwang Li, and Yali Jia "Automated three-dimensional registration and volume rebuilding for wide-field angiographic and structural optical coherence tomography," Journal of Biomedical Optics 22(2), 026001 (1 February 2017). https://doi.org/10.1117/1.JBO.22.2.026001

Received: 9 November 2016; Accepted: 9 January 2017; Published: 1 February 2017

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