Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis

Bernhard B. Zimmermann; Bin Deng; Bhawana Singh; Mark Martino; Juliette J. Selb; Qianqian Fang; Amir Y. Sajjadi; Jayne A. Cormier; Richard H. Moore; Daniel B. Kopans; David A. Boas; Mansi A. Saksena; Stefan A. Carp

doi:10.1117/1.JBO.22.4.046008

27 April 2017 Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis

Bernhard B. Zimmermann, Bin Deng, Bhawana Singh, Mark Martino, Juliette J. Selb, Qianqian Fang, Amir Y. Sajjadi, Jayne A. Cormier, Richard H. Moore, Daniel B. Kopans, David A. Boas, Mansi A. Saksena, Stefan A. Carp

Author Affiliations +

Journal of Biomedical Optics, Vol. 22, Issue 4, 046008 (April 2017). https://doi.org/10.1117/1.JBO.22.4.046008

Abstract

Diffuse optical tomography (DOT) is emerging as a noninvasive functional imaging method for breast cancer diagnosis and neoadjuvant chemotherapy monitoring. In particular, the multimodal approach of combining DOT with x-ray digital breast tomosynthesis (DBT) is especially synergistic as DBT prior information can be used to enhance the DOT reconstruction. DOT, in turn, provides a functional information overlay onto the mammographic images, increasing sensitivity and specificity to cancer pathology. We describe a dynamic DOT apparatus designed for tight integration with commercial DBT scanners and providing a fast (up to 1 Hz) image acquisition rate to enable tracking hemodynamic changes induced by the mammographic breast compression. The system integrates 96 continuous-wave and 24 frequency-domain source locations as well as 32 continuous wave and 20 frequency-domain detection locations into low-profile plastic plates that can easily mate to the DBT compression paddle and x-ray detector cover, respectively. We demonstrate system performance using static and dynamic tissue-like phantoms as well as in vivo images acquired from the pool of patients recalled for breast biopsies at the Massachusetts General Hospital Breast Imaging Division.

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Bernhard B. Zimmermann, Bin Deng, Bhawana Singh, Mark Martino, Juliette J. Selb, Qianqian Fang, Amir Y. Sajjadi, Jayne A. Cormier, Richard H. Moore, Daniel B. Kopans, David A. Boas, Mansi A. Saksena, and Stefan A. Carp "Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis," Journal of Biomedical Optics 22(4), 046008 (27 April 2017). https://doi.org/10.1117/1.JBO.22.4.046008

Received: 15 December 2016; Accepted: 7 April 2017; Published: 27 April 2017

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