Accurate viscosity measurements of flowing aqueous glucose solutions with suspended scatterers using a dynamic light scattering approach with optical coherence tomography

Andrew Weatherbee; Ivan Popov; Alex Vitkin

doi:10.1117/1.JBO.22.8.087003

31 August 2017 Accurate viscosity measurements of flowing aqueous glucose solutions with suspended scatterers using a dynamic light scattering approach with optical coherence tomography

Andrew Weatherbee, Ivan Popov, Alex Vitkin

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Journal of Biomedical Optics, Vol. 22, Issue 8, 087003 (August 2017). https://doi.org/10.1117/1.JBO.22.8.087003

Abstract

The viscosity of turbid colloidal glucose solutions has been accurately determined from spectral domain optical coherence tomography (OCT) M-mode measurements and our recently developed OCT dynamic light scattering model. Results for various glucose concentrations, flow speeds, and flow angles are reported. The relative “combined standard uncertainty” uc(η) on the viscosity measurements was ±1% for the no-flow case and ±5% for the flow cases, a significant improvement in measurement robustness over previously published reports. The available literature data for the viscosity of pure water and our measurements differ by 1% (stagnant case) and 1.5% (flow cases), demonstrating good accuracy; similar agreement is seen across the measured glucose concentration range when compared to interpolated literature values. The developed technique may contribute toward eventual noninvasive glucose measurements in medicine.

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Andrew Weatherbee, Ivan Popov, and Alex Vitkin "Accurate viscosity measurements of flowing aqueous glucose solutions with suspended scatterers using a dynamic light scattering approach with optical coherence tomography," Journal of Biomedical Optics 22(8), 087003 (31 August 2017). https://doi.org/10.1117/1.JBO.22.8.087003

Received: 24 February 2017; Accepted: 18 July 2017; Published: 31 August 2017

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