Dynamic in vivo imaging of small animal brain using pulsed laser diode-based photoacoustic tomography system

Paul Kumar Upputuri; Manojit Pramanik

doi:10.1117/1.JBO.22.9.090501

26 September 2017 Dynamic in vivo imaging of small animal brain using pulsed laser diode-based photoacoustic tomography system

Paul Kumar Upputuri, Manojit Pramanik

Author Affiliations +

Journal of Biomedical Optics, Vol. 22, Issue 9, 090501 (September 2017). https://doi.org/10.1117/1.JBO.22.9.090501

Abstract

We demonstrate dynamic in vivo imaging using a low-cost portable pulsed laser diode (PLD)-based photoacoustic tomography system. The system takes advantage of an 803-nm PLD having high-repetition rate ∼7000 Hz combined with a fast-scanning single-element ultrasound transducer leading to a 5 s cross-sectional imaging. Cortical vasculature is imaged in scan time of 5 s with high signal-to-noise ratio ∼48. To examine the ability for dynamic imaging, we monitored the fast uptake and clearance process of indocyanine green in the rat brain. The system will find applications to study neurofunctional activities, characterization of pharmacokinetic, and biodistribution profiles in the development process of drugs or imaging agents.

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Paul Kumar Upputuri and Manojit Pramanik "Dynamic in vivo imaging of small animal brain using pulsed laser diode-based photoacoustic tomography system," Journal of Biomedical Optics 22(9), 090501 (26 September 2017). https://doi.org/10.1117/1.JBO.22.9.090501

Received: 16 June 2017; Accepted: 5 September 2017; Published: 26 September 2017

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KEYWORDS

Imaging systems

Brain

In vivo imaging

Neuroimaging

Acquisition tracking and pointing

Signal to noise ratio

Photoacoustic tomography

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