Contrast-enhanced photoacoustic imaging in the second near-infrared window using semiconducting polymer nanoparticles

Paul Kumar Upputuri; Cangjie Yang; Shuo Huang; Kai Wang; Mingfeng Wang; Manojit Pramanik

doi:10.1117/1.JBO.24.3.031002

17 August 2018 Contrast-enhanced photoacoustic imaging in the second near-infrared window using semiconducting polymer nanoparticles

Paul Kumar Upputuri, Cangjie Yang, Shuo Huang, Kai Wang, Mingfeng Wang, Manojit Pramanik

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Journal of Biomedical Optics, Vol. 24, Issue 3, 031002 (August 2018). https://doi.org/10.1117/1.JBO.24.3.031002

Abstract

Photoacoustic imaging (PAI) is a fast growing deep-tissue imaging modality. However, light scattering and absorption in biological tissues limit imaging depth. Short near-infrared wavelengths (650 to 950 nm) are widely used for PAI. Using longer near-infrared wavelengths reduces scattering. We demonstrate deep-tissue contrast-enhanced in vivo photoacoustic imaging at a wavelength of 1064 nm. An ultranarrow bandgap semiconducting polymer poly (thienoisoindigo-alt-diketopyrrolopyrrole) (denoted as PIGD) is designed and demonstrated for imaging at 1064 nm. By embedding colloidal nanoparticles (NPs) of PIGD in chicken-breast tissue, an imaging depth of ∼5 cm is achieved. Intravenous injection of PIGD NPs in living rats showed brain vascular images with ∼2 times higher contrast compared with the brain vascular images without any contrast agent. Thus, PIGD NPs as an NIR-II contrast agent opens new opportunities for both preclinical and clinical imaging of deep tissues with enhanced contrast.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Paul Kumar Upputuri, Cangjie Yang, Shuo Huang, Kai Wang, Mingfeng Wang, and Manojit Pramanik "Contrast-enhanced photoacoustic imaging in the second near-infrared window using semiconducting polymer nanoparticles," Journal of Biomedical Optics 24(3), 031002 (17 August 2018). https://doi.org/10.1117/1.JBO.24.3.031002

Received: 19 February 2018; Accepted: 21 May 2018; Published: 17 August 2018

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