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20 June 2019 Plasmonic imaging of subcellular electromechanical deformation in mammalian cells
Yunze Yang, Xianwei Liu, Shaopeng Wang, Nongjian Tao
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Journal of Biomedical Optics, Vol. 24, Issue 6, 066007 (June 2019). https://doi.org/10.1117/1.JBO.24.6.066007
Abstract
A membrane potential change in cells is accompanied with mechanical deformation. This electromechanical response can play a significant role in regulating action potential in neurons and in controlling voltage-gated ion channels. However, measuring this subtle deformation in mammalian cells has been a difficult task. We show a plasmonic imaging method to image mechanical deformation in single cells upon a change in the membrane potential. Using this method, we have studied the electromechanical response in mammalian cells and have observed the local deformation within the cells that are associated with cell–substrate interactions. By analyzing frequency dependence of the response, we have further examined the electromechanical deformation in terms of mechanical properties of cytoplasm and cytoskeleton. We demonstrate a plasmonic imaging approach to quantify the electromechanical responses of single mammalian cells and determine local variability related to cell–substrate interactions.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Yunze Yang, Xianwei Liu, Shaopeng Wang, and Nongjian Tao "Plasmonic imaging of subcellular electromechanical deformation in mammalian cells," Journal of Biomedical Optics 24(6), 066007 (20 June 2019). https://doi.org/10.1117/1.JBO.24.6.066007
Received: 25 February 2019; Accepted: 30 May 2019; Published: 20 June 2019
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Cited by 11 scholarly publications.
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KEYWORDS
Plasmonic imaging
Plasmonics
Modulation
Phase shift keying
Polarization
Gold
Cytoskeletons
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