Water and lipid content of breast tissue measured by six-wavelength time-domain diffuse optical spectroscopy

Hiroko Wada; Nobuko Yoshizawa; Etsuko Ohmae; Yukio Ueda; Kenji Yoshimoto; Tetsuya Mimura; Hatsuko Nasu; Yuko Asano; Hiroyuki Ogura; Harumi Sakahara; Satoshi Goshima

doi:10.1117/1.JBO.27.10.105002

13 October 2022 Water and lipid content of breast tissue measured by six-wavelength time-domain diffuse optical spectroscopy

Hiroko Wada, Nobuko Yoshizawa, Etsuko Ohmae, Yukio Ueda, Kenji Yoshimoto, Tetsuya Mimura, Hatsuko Nasu, Yuko Asano, Hiroyuki Ogura, Harumi Sakahara, Satoshi Goshima

Author Affiliations +

Journal of Biomedical Optics, Vol. 27, Issue 10, 105002 (October 2022). https://doi.org/10.1117/1.JBO.27.10.105002

Abstract

Significance

The water and lipid content of normal breast tissue showed mammary gland characteristics with less influence from the chest wall using six-wavelength time-domain diffuse optical spectroscopy (TD-DOS) in a reflectance geometry.

Aim

To determine the depth sensitivity of a six-wavelength TD-DOS system and evaluate whether the optical parameters in normal breast tissue can distinguish dense breasts from non-dense breasts.

Approach

Measurements were performed in normal breast tissue of 37 breast cancer patients. We employed a six-wavelength TD-DOS system to measure the water and lipid content in addition to the hemoglobin concentration. The breast density in mammography and optical parameters were then compared.

Results

The depth sensitivity of the system for water and lipid content was estimated to be ∼15 mm. Our findings suggest that the influence of the chest wall on the water content is weaker than that on the total hemoglobin concentration. In data with evaluation conditions, the water content was significantly higher (p < 0.001) and the lipid content was significantly lower (p < 0.001) in dense breast tissue. The water and lipid content exhibited a high sensitivity and specificity to distinguish dense from non-dense breasts in receiver-operating-characteristic curve analysis.

Conclusions

With less influence from the chest wall, the water and lipid content of normal breast tissue measured by a reflectance six-wavelength TD-DOS system, together with ultrasonography, can be applied to distinguish dense from non-dense breasts.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Hiroko Wada, Nobuko Yoshizawa, Etsuko Ohmae, Yukio Ueda, Kenji Yoshimoto, Tetsuya Mimura, Hatsuko Nasu, Yuko Asano, Hiroyuki Ogura, Harumi Sakahara, and Satoshi Goshima "Water and lipid content of breast tissue measured by six-wavelength time-domain diffuse optical spectroscopy," Journal of Biomedical Optics 27(10), 105002 (13 October 2022). https://doi.org/10.1117/1.JBO.27.10.105002

Received: 9 February 2022; Accepted: 23 September 2022; Published: 13 October 2022

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