Multimodal optical imaging with real-time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatment

Jackson B. Coole; David R. Brenes; Ruchika Mitbander; Imran S. Vohra; Huayu Hou; Alex Kortum; Yubo Tang; Yajur Maker; Richard A. Schwarz; Jennifer L. Carns; Hawraa Badaoui; Michelle D. Williams; Nadarajah Vigneswaran; Ann M. Gillenwater; Rebecca Richards-Kortum

doi:10.1117/1.JBO.28.1.016002

13 January 2023 Multimodal optical imaging with real-time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatment

Jackson B. Coole, David R. Brenes, Ruchika Mitbander, Imran S. Vohra, Huayu Hou, Alex Kortum, Yubo Tang, Yajur Maker, Richard A. Schwarz, Jennifer L. Carns, Hawraa Badaoui, Michelle D. Williams, Nadarajah Vigneswaran, Ann M. Gillenwater, Rebecca Richards-Kortum

Author Affiliations +

Journal of Biomedical Optics, Vol. 28, Issue 1, 016002 (January 2023). https://doi.org/10.1117/1.JBO.28.1.016002

Abstract

Significance

Despite recent advances in multimodal optical imaging, oral imaging systems often do not provide real-time actionable guidance to the clinician who is making biopsy and treatment decisions.

Aim

We demonstrate a low-cost, portable active biopsy guidance system (ABGS) that uses multimodal optical imaging with deep learning to directly project cancer risk and biopsy guidance maps onto oral mucosa in real time.

Approach

Cancer risk maps are generated based on widefield autofluorescence images and projected onto the at-risk tissue using a digital light projector. Microendoscopy images are obtained from at-risk areas, and multimodal image data are used to calculate a biopsy guidance map, which is projected onto tissue.

Results

Representative patient examples highlight clinically actionable visualizations provided in real time during an imaging procedure. Results show multimodal imaging with cancer risk and biopsy guidance map projection offers a versatile, quantitative, and precise tool to guide biopsy site selection and improve early detection of oral cancers.

Conclusions

The ABGS provides direct visible guidance to identify early lesions and locate appropriate sites to biopsy within those lesions. This represents an opportunity to translate multimodal imaging into real-time clinically actionable visualizations to help improve patient outcomes.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Jackson B. Coole, David R. Brenes, Ruchika Mitbander, Imran S. Vohra, Huayu Hou, Alex Kortum, Yubo Tang, Yajur Maker, Richard A. Schwarz, Jennifer L. Carns, Hawraa Badaoui, Michelle D. Williams, Nadarajah Vigneswaran, Ann M. Gillenwater, and Rebecca Richards-Kortum "Multimodal optical imaging with real-time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatment," Journal of Biomedical Optics 28(1), 016002 (13 January 2023). https://doi.org/10.1117/1.JBO.28.1.016002

Received: 25 October 2022; Accepted: 28 December 2022; Published: 13 January 2023

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