Determination of tissue oxygen saturation by diffuse reflectance spectroscopy

Laura Lucía Sánchez-Ramos; Beatriz Morales-Cruzado; Francisco Gerardo Pérez-Gutiérrez

doi:10.1117/1.JBO.28.9.095002

28 September 2023 Determination of tissue oxygen saturation by diffuse reflectance spectroscopy

Laura Lucía Sánchez-Ramos, Beatriz Morales-Cruzado, Francisco Gerardo Pérez-Gutiérrez

Author Affiliations +

Journal of Biomedical Optics, Vol. 28, Issue 9, 095002 (September 2023). https://doi.org/10.1117/1.JBO.28.9.095002

Abstract

Significance

Tissue oxygenation is a parameter that allows for determining the health status of human beings. In diabetic patients, it is particularly important to evaluate this parameter as an indicator of microcirculatory problems in the extremities.

Aim

We aim to obtain tissue oxygen saturation from diffuse reflectance measurements.

Approach

A computational algorithm to automate the methodology was implemented with the aim of establishing a medical diagnosis technique that is non-invasive and easy to apply and requires a short evaluation time. Tissue oxygen saturation measurements were performed on a group of volunteers to whom a vascular occlusion was applied. It was observed that, by increasing the applied pressure to the arm of each volunteer, the tissue oxygen saturation progressively decreased.

Results

The results indicate that the developed technique is an effective method for monitoring changes in blood hemodynamics in patients with some type of pathology in which tissue oxygenation is compromised. In addition, the expected behavior of tissue oxygen saturation during a vascular occlusion was obtained.

Conclusions

A methodology to obtain tissue oxygen saturation from diffuse reflectance measurements was successfully developed. It meets the necessary characteristics to be considered a technique for obtaining StO₂ because it can be applied in vivo and non-invasively and does not require a high computational cost; thus it is fast and capable of providing an objective and quantifiable evaluation.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Laura Lucía Sánchez-Ramos, Beatriz Morales-Cruzado, and Francisco Gerardo Pérez-Gutiérrez "Determination of tissue oxygen saturation by diffuse reflectance spectroscopy," Journal of Biomedical Optics 28(9), 095002 (28 September 2023). https://doi.org/10.1117/1.JBO.28.9.095002

Received: 27 February 2023; Accepted: 13 September 2023; Published: 28 September 2023

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KEYWORDS

Tissues

Oxygen

Skin

Absorption

Oxygenation

Diffuse reflectance spectroscopy

Blood pressure

Significance

Aim

Approach

Results

Conclusions

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