Activated rate processes and a specific biochemical mechanism for explaining delayed laser induced thermal damage to the retina

Bernard S. Gerstman; Randolph D. Glickman

doi:10.1117/1.429936

1 July 1999 Activated rate processes and a specific biochemical mechanism for explaining delayed laser induced thermal damage to the retina

Bernard S. Gerstman, Randolph D. Glickman

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Journal of Biomedical Optics, Vol. 4, Issue 3, (July 1999). https://doi.org/10.1117/1.429936

Laser induced thermal damage to the retina is investigated. The one step Arrhenius type thermal damage integral of Henriques is analyzed for its strengths and weaknesses. The zero-order activated rate process is shown to well represent the data for pulse durations greater than 10 µs. A zero-order biochemical damage mechanism involving free radical formation and thermal disruption of the melanosome’s protein coat is proposed as the initial molecular process that leads to cellular damage which appears after a delay. Data are presented that show the photoactivation of melanin granule oxidative reactivity. This in vitro data is evidence for an important step in our hypothesized damage pathway.

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Bernard S. Gerstman and Randolph D. Glickman "Activated rate processes and a specific biochemical mechanism for explaining delayed laser induced thermal damage to the retina," Journal of Biomedical Optics 4(3), (1 July 1999). https://doi.org/10.1117/1.429936

Published: 1 July 1999

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