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2 December 2013 Nondestructive evaluation of crystallized-particle size in lactose-powder by terahertz time-domain spectroscopy
Satoshi Yamauchi, Sakura Hatakeyama, Yoh Imai, Masayoshi Tonouchi
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Optical Engineering, Vol. 53, Issue 3, 031203 (December 2013). https://doi.org/10.1117/1.OE.53.3.031203
Abstract
Transmission-type terahertz time-domain spectroscopy is applied to evaluate crystallized lactose particle of size below 30 μm, which is far too small compared to the wavelength of incident terahertz (THz)-wave. The THz-absorption spectrum of lactose is successfully deconvoluted by Lorentzian to two spectra with peaks at 17.1  cm[sup]−1 (0.53 THz) and 45.6  cm −1 (1.37 THz) derived from α -lactose monohydrate, and a spectrum at 39.7  cm−1 (1.19 THz) from anhydrous β-lactose after removal of the broad-band spectrum by polynomial cubic function. Lactose is mainly crystallized into α -lactose monohydrate from the supersaturated solution at room temperature with a small amount of anhydrous β-lactose below 4%. The absorption feature is dependent on the crystallized particle size and the integrated intensity ratio of the two absorptions due to α-lactose monohydrate is correlated in linear for the size.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Satoshi Yamauchi, Sakura Hatakeyama, Yoh Imai, and Masayoshi Tonouchi "Nondestructive evaluation of crystallized-particle size in lactose-powder by terahertz time-domain spectroscopy," Optical Engineering 53(3), 031203 (2 December 2013). https://doi.org/10.1117/1.OE.53.3.031203
Published: 2 December 2013
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Cited by 10 scholarly publications.
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KEYWORDS
Crystals
Particles
Absorption
Terahertz spectroscopy
Terahertz radiation
Spectroscopy
Nondestructive evaluation
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