In clinical dermatology, understanding collagen remodeling and reorganization are most important. Collagen provides the support matrix underpinning healthy skin and is key to preserving skin firmness and elasticity. Any issue with collagen deposition and deviation would affect the appearance in skin. In this regard, an ability to monitor the morphological changes in collagen organizations along with vascular morphology may improve our understanding in its pathophysiology and, ultimately, prevent these abnormal conditions. In this effort, we developed an advanced single input in house-built polarization-sensitive optical coherence tomography (PSOCT) device to directly visualize collagen organization within skin in vivo in various dermatological conditions like lipoatrophy, Necrobiosis lipoidica diabeticorum, and surgical scars to show the clinical utility of the system.
This paper presents a hand-held single-mode fiber-based polarization-sensitive optical coherence tomography (PS-OCT) system with a single input polarization state. One drawback of this system is that the polarization becomes arbitrary, which can be solved by placing a polarization controller in the sample arm. A calibration target with an azimuthally varying optic axis integrated with the handheld probe will provide an absolute orientation axis measurement. This significantly reduces cost, time and availability of PS-OCT for clinical applications. With the home-built PS-OCT, we investigate the reorganization of collagen and blood vessel in a wound on the dorsal side of the human hand.
Studies on propagation of linearly and circularly polarized vortex beams in tissue-like forward scattering turbid media revealed longer survival of vortex beams with higher topological charge (l). It is shown that an increase in the effective anisotropy parameter of scattering as seen by vortex beams having higher topological charge (l) is responsible for the observed longer survival of vortex beams in tissue and tissue-like turbid media. These findings may open up interesting avenues towards achieving larger depth of imaging in biological tissues by appropriately tailoring orbital angular momentum and spatial polarization states of vector vortex beams.
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