We present a novel ultrafast imaging system using Spatio-Temporal Optical Coherence Tomography (STOC-T), capable of acquiring structural images of a mouse retina at a volumetric rate of 112 Hz, aided by a calibrated fundus camera for focal plane adjustment. We extract blood pulse traces from retinal and choroidal vessels using a structural-only OCT analysis, and pulse wave-induced retinal layer displacement from differential OCT phase analysis. With both analyses, we measure hemodynamic parameters, such as the delays between arterial and venous pulsation, to provide a comprehensive suite of potential biomarkers of retinal diseases.
We present a novel ultrafast imaging system using Spatio-Temporal Optical Coherence Tomography (STOC-T), capable of acquiring structural images of a mouse retina at a volumetric rate of 112 Hz. A calibrated fundus camera and white-light illumination aid the alignment of the mouse and the adjustment of the focal plane in the mouse retina for the STOC-T image. We extract pulsatile blood flow frequency and other hemodynamic parameters from multiple retinal and choroidal vessels from structural-only OCT images, highlighting the prospects of STOC-T for monitoring retinal hemodynamics in a simple way.
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