Dr. Chi-Hsiang Lien Profile

Dr. Chi-Hsiang Lien

Assistant Professor at National United Univ

SPIE Involvement:

Author

Area of Expertise:

Mueller polarimetry , Collagen , Second harmonic generation imaging

Chi-Hsiang Lien is an assistant professor of Mechanical Engineering in National United University and received his B.S. degree in Mechanical Engineering from National United University in 2008 and his Ph.D degree in Engineering Science from National Cheng Kung University in 2014. He was invited to work with Prof. Paul J. Campagnola in UW-Madison from Jan. 2012 to July 2013. He is the author of more than 20 journal papers and has written about Mueller polarimetry, temporal focusing microscopy techniques, and polarization second harmonic generation imaging and analysis techniques for collagen. His current research interests include nonlinear optics in biological microscopy and polarization optics for biomedical applications.

Proceedings Article | 3 October 2024 Presentation

Categorization of collagen hydrogels using multipolarization SHG imaging with deep learning

Chi-Hsiang Lien, Chung-Hwan Chen, Anupama Nair, Chun-Yu Lin, Shu-Chun Chuang, Shean-Jen Chen

Proceedings Volume 13139, 131390F (2024) https://doi.org/10.1117/12.3032685

KEYWORDS: Collagen, Second harmonic generation, Hydrogels, Deep learning, Polarization, Matrices, Tissues, Polarization control, Mixtures, Microscopy

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Proceedings Article | 12 August 2023 Presentation

High-resolution imaging and modeling of collagen architecture alterations in high-grade serous ovarian cancer

Paul Campagnola, Farid Atry, Samuel Alkmin, Vikas Singh, Bruce Wen, Kirby Campbell, Manish Patankar, Melissa Champer, Chi-Hsiang Lien

Proceedings Volume PC12622, PC126220O (2023) https://doi.org/10.1117/12.2678187

KEYWORDS: Collagen, Ovarian cancer, Second harmonic generation, Modeling, Image resolution, Tissues, Machine learning, Diseases and disorders, Cancer, Tumors

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Proceedings Article | 15 March 2023 Presentation

Analysis of the different type collagen with pixel-resolution by Dual-LC PSHG microscopy (Conference Presentation)

Chi-Hsiang Lien, Anupama Nair, Shu‐Chun Chuang, Yi-Shan Lin, Chun-Yu Lin, Chung-Hwan Chen, Shean-Jen Chen

Proceedings Volume PC12384, PC123840P (2023) https://doi.org/10.1117/12.2650478

KEYWORDS: Collagen, Microscopy, Second-harmonic generation, Polarization, Anisotropy, Tissues, Modulation, Liquid crystals, Quantitative analysis, Proteins

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Proceedings Article | 27 May 2022 Presentation + Paper

Analysis of collagen types I and II at bone fracture healing tissue using polarization SHG

Anupama Nair, Shu-Chun Chuang, Yi-Shan Lin, Chung-Hwan Chen, Chi-Hsiang Lien, Shean-Jen Chen

Proceedings Volume 12144, 121440J (2022) https://doi.org/10.1117/12.2621568

KEYWORDS: Collagen, Bone, Tissues, Polarization, Cartilage, Second-harmonic generation, Liquid crystals, Harmonic generation, Proteins, Medical research

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Proceedings Article | 4 March 2019 Presentation

The features of temporal focusing multiphoton excitation fluorescence microscopy using the different excitation wavelength (Conference Presentation)

Fan-Ching Chien, Chun-Yu Lin, Chia-Yuan Chang, Chi-Hsiang Lien

Proceedings Volume 10882, 108821L (2019) https://doi.org/10.1117/12.2508141

KEYWORDS: Multiphoton microscopy, Microscopy, Luminescence, Multiphoton fluorescence microscopy, Absorption, Optical scanning systems, Polarization, Pulsed laser operation, Diffraction, Microscopes

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Proceedings Article | 24 April 2017 Presentation

Dynamical measurements of motion behavior of free fluorescent sphere using the wide field temporal focusing microscopy with astigmatism method (Conference Presentation)

Chi-Hsiang Lien, Chun-Yu Lin, Shean-Jen Chen, Fan-Ching Chien

Proceedings Volume 10069, 100691V (2017) https://doi.org/10.1117/12.2252323

KEYWORDS: Biomedical optics, 3D image processing, Multiphoton microscopy, Monochromatic aberrations, 3D metrology, Microscopy, Particles, Motion measurement, Optical spheres, 3D scanning

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SPIE Journal Paper | 23 February 2017 Open Access

Two-color temporal focusing multiphoton excitation imaging with tunable-wavelength excitation

Chi-Hsiang Lien, Gerald Abrigo, Pei-Hsuan Chen, Fan-Ching Chien

JBO, Vol. 22, Issue 02, 026008, (February 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.2.026008

KEYWORDS: Luminescence, Diffraction, Diffraction gratings, Imaging systems, Optical fibers, Objectives, Microscopy, Thin films, Beam expanders, Light

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Proceedings Article | 19 October 2012 Paper

Fast multiphoton microfabrication of freeform polymer microstructures by spatiotemporal focusing and patterned generation

Y.-C. Li, L.-C. Cheng, C.-H. Lien, C.-Y. Chang, W.-C. Yen, S.-J. Chen

Proceedings Volume 8489, 848905 (2012) https://doi.org/10.1117/12.930307

KEYWORDS: Microfabrication, Polymers, Digital micromirror devices, 3D microstructuring, Optical amplifiers, Objectives, Ultrafast phenomena, Inspection, 3D image processing, Image processing

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Proceedings Article | 27 September 2012 Paper

Mechanism of two-photon fluorescence increment via cross-linked bovine serum albumin

C.-Y. Lin, C.-H. Lien, C.-Y. Chang, S.-J Chen

Proceedings Volume 8459, 84590F (2012) https://doi.org/10.1117/12.930335

KEYWORDS: Quantum efficiency, Luminescence, Femtosecond phenomena, Fluorescence lifetime imaging, Picosecond phenomena, Laser development, Molecules, Rhodamine B, Photons, Field programmable gate arrays

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Proceedings Article | 6 February 2012 Paper

Three-dimensional gold nanorods-doped multicolor microstructures

C.-H. Lien, K.-C. Cho, W.-S. Kuo, C.-Y. Lin, C.-L. Chui, S.-J. Chen

Proceedings Volume 8234, 82341R (2012) https://doi.org/10.1117/12.914044

KEYWORDS: 3D microstructuring, Plasmons, Proteins, Microfabrication, Femtosecond phenomena, Gold, Plasmonics, 3D image processing, Photochemistry, Absorption

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Proceedings Article | 11 September 2010 Paper

Three-dimensional polymer microdevices with gold nanorods

W.-S. Kuo, C.-H. Lien, K.-C. Cho, C.-Y. Chang, C.-Y. Lin, P. Campagnola, S.-J. Chen

Proceedings Volume 7757, 77573C (2010) https://doi.org/10.1117/12.864099

KEYWORDS: 3D microstructuring, Femtosecond phenomena, Polymers, Plasmons, Absorption, Gold, Bragg cells, Laser damage threshold, Microfabrication, Field programmable gate arrays

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Proceedings Article | 11 September 2010 Paper

Surface plasmon-enhanced and quenched two-photon excited fluorescence

C.-Y. Lin, C.-H. Lien, K.-C. Chiu, C.-Y. Chang, S.-H. Chang, T.-F. Guo, S.-J. Chen

Proceedings Volume 7757, 77573A (2010) https://doi.org/10.1117/12.864042

KEYWORDS: Luminescence, Quantum efficiency, Silver, Metals, Silica, Reflection, Surface plasmons, Microscopy, Dielectrics, Objectives

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