We report a novel nanophotonic biosensor surface capable of both colorimetric detection and Raman-scattered detection of DNA infection markers at extreme sensitivities. Combining direct-write lithography, dip-pen nanolithography based DNA patterning, and molecular self-assembly, we create molecularly-active plasmonic nanostructures onto which metallic nanoparticles are located via DNA-hybridization. Arraying these structures enables optical surfaces that change state when contacted by specific DNA sequences; shifting the surface color while simultaneously generating strong Raman-scattering signals. Patterning the DNA markers onto the plasmonic surface as micro-scale symbols results in easily identifiable color shifts, making this technique applicable to multiplexed lab-on-a-chip and point-of-care diagnostic applications.
We demonstrate tunable, polarization-dependent, dual-color plasmonic filters based upon arrays of asymmetric cross-shaped nano-apertures. Acting as individual color emitting nano-pixels, each aperture can selectively transmit one of 2 colors, switched by controlling the polarization of white-light incident on the rear of each pixel. By tuning the dimensions of the pixels we build a polarization sensitive color palette at resolutions far beyond the diffraction limit. Using this switchable color palette we are able to generate complex optical surfaces encoded with dual color and information states; allowing us to embed two color images within the same unit area, using the same set of nanoapertures.
We report a versatile nanophotonic biosensing platform that enables both colorimetric detection and enhanced Raman spectroscopy detection of molecular binding events. Through the integration of electron-beam lithography, dip-pennanolithography and molecular self-assembly, we demonstrate plasmonic nanostructures which change geometry and plasmonic properties in response to molecularly-mediated nanoparticle binding events. These biologically-active nanostructured surfaces hold considerable potential for use as multiplexed sensor platforms for point-of-care diagnostics, and as scaffolds for a new generation of molecularly dynamic metamaterials.
Photoluminescence enhancement of CdSe/CdS/ZnS QDs by localized surface plasmon resonance of large Au-NPs has
been investigated. The photoluminescence of the QDs with an emission wavelength at 620 nm in a PMMA matrix is
enhanced by immobilized Au-NPs. By considering the lifetime and excitation dependent photoluminescence we realized
that the emission and excitation rate enhancements both contributed to the total photoluminescence enhancement. PL
measurements were carried out for different sizes of Au-NPs to find out their influences on the emission of QDs. The
largest enhancement is achieved by applying 80 nm Au-NPs. Silanization method gives us the opportunity easily to
prepare samples with different concentrations of Au-NPs. It is revealed that increasing the concentration of the Au-NPs
layer provides higher scattering cross section which contributes in PL enhancement.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.