This study presents an exploratory approach to performing optical coherence tomographic angiography (OCTA) using motion contrast between repeated volumetric scans captured at 200 ms intervals, as opposed to conventional OCTA which measure motion contrast between repeat B-scans captured at shorter intervals. The proposed inter-volumetric OCTA (IV-OCTA) is made possible through an advanced image registration algorithm based on Mattes mutual information metric, and it is implemented on an ultra-high-resolution spectral domain 840 nm OCT system with a 250 KHz A-scan rate. IV-OCTA demonstrates a high detection sensitivity for microvessels with slow blood flow and reduces bulk motion artifacts using the embedded volume registration algorithm. Meanwhile, averaging repeated volumes can substantially reduce the speckle noise for clearer structural imaging compared to the averaged repeated B-scans.
We introduced an improved iteration of a panoramic retinal (panretinal) handheld swept-source OCT angiography (OCTA) imaging system with an 800kHz VCSEL light source. The advanced system successfully achieved a remarkable 140° field of view (FOV, visual angle measured from the pupil plane), enabling comprehensive imaging coverage from the posterior pole to the peripheral retina in a single capture.
In this study we present a desktop swept-source optical coherence tomographic angiography (OCTA) system for a diverse range of ophthalmic applications. The system can achieve 500 kHz ultrafast imaging with a 75-degree field of view, assisted by a GPU-accelerated real-time cross-sectional and en face OCT/OCTA acquisition interface, a self-tracking method for motion correction, and an AI-based retinal layer segmentation algorithm. High-resolution and high-sensitivity OCTA images from different retinal disease types are demonstrated.
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