Dr. Hesheng Wang Profile

Dr. Hesheng Wang

Assistant Professor at NYU Langone Health

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Author

Publications (9)

Proceedings Article | 7 April 2023 Poster + Paper

The importance of data domain on self-supervised learning for brain metastasis detection and segmentation

Youngjin Yoo, Gengyan Zhao, Andreea Sandu, Thomas Re, Jyotipriya Das, Hesheng Wang, Michelle Kim, Colette Shen, Yueh Lee, Douglas Kondziolka, Mohannad Ibrahim, Jun Lian, Rajan Jain, Tong Zhu, Hemant Parmar, James Balter, Yue Cao, Eli Gibson, Dorin Comaniciu

Proceedings Volume 12465, 1246529 (2023) https://doi.org/10.1117/12.2653909

KEYWORDS: Data modeling, Performance modeling, 3D modeling, Brain, Cancer detection, Image segmentation, Magnetic resonance imaging, Neuroimaging

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Proceedings Article | 3 April 2023 Presentation + Paper

3D-2D GAN based brain metastasis synthesis with configurable parameters for fully 3D data augmentation

Gengyan Zhao, Youngjin Yoo, Thomas Re, Jyotipriya Das, Hesheng Wang, Michelle Kim, Colette Shen, Yueh Lee, Douglas Kondziolka, Mohannad Ibrahim, Jun Lian, Rajan Jain, Tong Zhu, Hemant Parmar, James Balter, Yue Cao, Eli Gibson, Dorin Comaniciu

Proceedings Volume 12464, 124640J (2023) https://doi.org/10.1117/12.2654281

KEYWORDS: Realistic image synthesis, Deep learning, Machine learning, Computer vision technology, Brain, Convolution, Magnetic resonance imaging, Neuroimaging, Image segmentation, Tumors

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Proceedings Article | 27 March 2009 Paper

An MRI-guided PET partial volume correction method

Hesheng Wang, Baowei Fei

Proceedings Volume 7259, 725928 (2009) https://doi.org/10.1117/12.812474

KEYWORDS: Positron emission tomography, Magnetic resonance imaging, Point spread functions, Tissues, Deconvolution, Convolution, Brain, 3D modeling, Monte Carlo methods, Neuroimaging

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Proceedings Article | 28 February 2009 Paper

Choline molecular imaging with small-animal PET for monitoring tumor cellular response to photodynamic therapy of cancer

Baowei Fei, Hesheng Wang, Chunying Wu, Joseph Meyers, Liang-Yan Xue, Gregory MacLennan, Mark Schluchter

Proceedings Volume 7262, 726211 (2009) https://doi.org/10.1117/12.812129

KEYWORDS: Tumors, Photodynamic therapy, Positron emission tomography, Cancer, Animal model studies, Tumor growth modeling, Prostate cancer, Molecular imaging, Tissues, Magnetic resonance imaging

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Proceedings Article | 27 February 2009 Paper

An MRI-based attenuation correction method for combined PET/MRI applications

Baowei Fei, Xiaofeng Yang, Hesheng Wang

Proceedings Volume 7262, 726208 (2009) https://doi.org/10.1117/12.813755

KEYWORDS: Signal attenuation, Positron emission tomography, Magnetic resonance imaging, Image segmentation, Tissues, Image registration, Image classification, Brain, Image processing, Computed tomography

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Proceedings Article | 10 May 2007 Paper

In vivo small animal imaging for early assessment of therapeutic efficacy of photodynamic therapy for prostate cancer

Baowei Fei, Hesheng Wang, Xiang Chen, Joseph Meyers, John Mulvilhill, Denise Feyes, Nancy Edgehouse, Jeffrey Duerk, Thomas Pretlow, Nancy Oleinick

Proceedings Volume 6511, 651102 (2007) https://doi.org/10.1117/12.708718

KEYWORDS: Photodynamic therapy, Tumors, Magnetic resonance imaging, Prostate cancer, In vivo imaging, Preclinical imaging, Cancer, Image segmentation, Image analysis, Medical imaging

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We are developing in vivo small animal imaging techniques that can measure early effects of photodynamic therapy (PDT) for prostate cancer. PDT is an emerging therapeutic modality that continues to show promise in the treatment of cancer. At our institution, a new second-generation photosensitizing drug, the silicon phthalocyanine Pc 4, has been developed and evaluated at the Case Comprehensive Cancer Center. In this study, we are developing magnetic resonance imaging (MRI) techniques that provide therapy monitoring and early assessment of tumor response to PDT. We generated human prostate cancer xenografts in athymic nude mice. For the imaging experiments, we used a highfield 9.4-T small animal MR scanner (Bruker Biospec). High-resolution MR images were acquired from the treated and control tumors pre- and post-PDT and 24 hr after PDT. We utilized multi-slice multi-echo (MSME) MR sequences. During imaging acquisitions, the animals were anesthetized with a continuous supply of 2% isoflurane in oxygen and were continuously monitored for respiration and temperature. After imaging experiments, we manually segmented the tumors on each image slice for quantitative image analyses. We computed three-dimensional T2 maps for the tumor regions from the MSME images. We plotted the histograms of the T2 maps for each tumor pre- and post-PDT and 24 hr after PDT. After the imaging and PDT experiments, we dissected the tumor tissues and used the histologic slides to validate the MR images. In this study, six mice with human prostate cancer tumors were imaged and treated at the Case Center for Imaging Research. The T2 values of treated tumors increased by 24 ± 14% 24 hr after the therapy. The control tumors did not demonstrate significant changes of the T2 values. Inflammation and necrosis were observed within the treated tumors 24 hour after the treatment. Preliminary results show that Pc 4-PDT is effective for the treatment of human prostate cancer in mice. The small animal MR imaging provides a useful tool to evaluate early tumor response to photodynamic therapy in mice.

Proceedings Article | 8 March 2007 Paper

Multiscale fuzzy C-means image classification for multiple weighted MR images for the assessment of photodynamic therapy in mice

Hesheng Wang, Denise Feyes, John Mulvihill, Nancy Oleinick, Gregory MacLennan, Baowei Fei

Proceedings Volume 6512, 65122W (2007) https://doi.org/10.1117/12.710188

KEYWORDS: Magnetic resonance imaging, Tumors, Image classification, Photodynamic therapy, Image filtering, Tissues, Fuzzy logic, Anisotropic filtering, Anisotropic diffusion, Image processing

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Proceedings Article | 13 March 2006 Paper

Finite element model-based tumor registration of microPET and high-resolution MR images for photodynamic therapy in mice

Baowei Fei, Hesheng Wang, Raymond Muzic, Chris Flask, Denise Feyes, David Wilson, Jeffrey Duerk, Nancy Oleinick

Proceedings Volume 6143, 61433I (2006) https://doi.org/10.1117/12.649531

KEYWORDS: Tumors, Image registration, Magnetic resonance imaging, Photodynamic therapy, Positron emission tomography, Image segmentation, Image fusion, Finite element methods, Brain, Neuroimaging

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Proceedings Article | 25 April 2005 Paper

Optical coherence tomography monitoring of cardiac ablation by high-intensity focused ultrasound

Matthew Ford, Yun Zhou, Hesheng Wang, Cheri Deng, Andrew Rollins

Proceedings Volume 5686, (2005) https://doi.org/10.1117/12.589288

KEYWORDS: Optical coherence tomography, Tissues, Ultrasonography, Natural surfaces, Heart, Image resolution, Acoustics, Tissue optics, Cavitation, In vivo imaging

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Showing 5 of 9 publications

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