Ms. Janelle Elise Phelps Profile

Janelle Elise Phelps

Research Assistant/Graduate Student at Duke Univ

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Publications (7)

SPIE Journal Paper | 1 January 2010 Open Access

Preferential accumulation of 5-aminolevulinic acid-induced protoporphyrin IX in breast cancer: a comprehensive study on six breast cell lines with varying phenotypes

Stacy Millon, Julie Ostrander, Siavash Yazdanfar, J. Quincy Brown, Janelle Bender, Anita Rajeha, Nirmala Ramanujam

JBO, Vol. 15, Issue 01, 018002, (January 2010) https://doi.org/10.1117/12.10.1117/1.3302811

KEYWORDS: Luminescence, Breast cancer, Confocal microscopy, Breast, Tissues, Cancer, Tumors, Imaging spectroscopy, Fluorescence spectroscopy, Tissue optics

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SPIE Journal Paper | 1 November 2008 Open Access

Cost-effective diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering in vivo

Bing Yu, Justin Lo, Thomas Kuech, Gregory Palmer, Janelle Bender, Nirmala Ramanujam

JBO, Vol. 13, Issue 06, 060505, (November 2008) https://doi.org/10.1117/12.10.1117/1.3041500

KEYWORDS: Tissue optics, Scattering, Absorption, Photodiodes, Optical properties, Tissues, Imaging spectroscopy, In vivo imaging, Imaging systems, Diffuse reflectance spectroscopy

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Proceedings Article | 2 March 2006 Paper

The effect of detector resolution for quantitative analysis of neutron stimulated emission computed tomography

Janelle Bender, Carey Floyd, Brian Harrawood, Anuj Kapadia, Amy Sharma, Jonathan Jesneck

Proceedings Volume 6142, 61424Z (2006) https://doi.org/10.1117/12.652812

KEYWORDS: Sensors, Breast, Tissues, Monte Carlo methods, Tumor growth modeling, Germanium, Computed tomography, Data modeling, Zinc, Scintillators

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Proceedings Article | 2 March 2006 Paper

Rotating slat collimator design for high-energy near-field imaging

Amy Sharma, Carey Floyd, Brian Harrawood, Georgia Tourassi, Anuj Kapadia, Janelle Bender, Joseph Lo, Calvin Howell

Proceedings Volume 6142, 614217 (2006) https://doi.org/10.1117/12.653929

KEYWORDS: Collimators, Sensors, Spectroscopy, Reconstruction algorithms, Near field, Imaging spectroscopy, Gamma radiation, Modulation, MATLAB, Solar energy

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Certain elements (such as Fe, Cu, Zn, etc.) are vital to the body and an imbalance of such elements can either be a symptom or cause of certain pathologies. Neutron Stimulated Emission Computed Tomography (NSECT) is a spectroscopic imaging technique whereby the body is illuminated via a beam of neutrons causing elemental nuclei to become excited and emit characteristic gamma radiation. Acquiring the gamma energy spectra in a tomographic geometry allows reconstruction of elemental concentration images. Previously we have demonstrated the feasibility of NSECT using first generation CT approaches; while successful, the approach does not scale well and has limited resolution. Additionally, current gamma cameras operate in an energy range too low for NSECT imaging. However, the orbiting Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) captures and images gamma rays over the high-energy range equivalent to NSECT's (3 keV to 17 MeV) by utilizing Collimator-based Fourier transform imaging. A High Purity Germanium (HPGe) detector counts the number of energy events per unit of time, providing spectroscopic data. While a pair of rotating collimators placed in front of the detector modulates the number of gamma events, providing spatial information. Knowledge of the number of energy events at each discrete collimator angle allows for 2D image reconstruction. This method has proven successful at a focus of infinity in the RHESSI application. Our goal is to achieve similar results at a reasonable near-field focus. Here we describe the results of our simulations to implement a rotating modulation collimator (RMC) gamma imager for use in NSECT using simulations in Matlab. To determine feasible collimator setups and the stability of the inverse problem a Matlab environment was created that uses the geometry of the system to generate 1D observation data from 2D images and then to reconstruct 2D images using the MLEM algorithm. Reasonable collimator geometries were determined, successful reconstruction was achieved and the inverse problem was found to be stable.

Proceedings Article | 2 March 2006 Paper

Breast cancer diagnosis using neutron stimulated emission computed tomography: dose and count requirements

Carey Floyd Jr., Janelle Bender, Brian Harrawood, Amy Sharma, Anuj Kapadia, Georgia Tourassi, Joseph Lo, Calvin Howell

Proceedings Volume 6142, 61421O (2006) https://doi.org/10.1117/12.656045

KEYWORDS: Breast, Tissues, Bromine, Zinc, Breast cancer, Cesium, Rubidium, Mammography, Cobalt, Tumor growth modeling

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SPIE Journal Paper | 1 July 2005 Open Access

Depth-sensitive reflectance measurements using obliquely oriented fiber probes

Adrien Wang, Janelle Bender, Josh Pfefer, Urs Utzinger, Rebekah Drezek

JBO, Vol. 10, Issue 04, 044017, (July 2005) https://doi.org/10.1117/12.10.1117/1.1989335

KEYWORDS: Reflectivity, Tissue optics, Photons, Tissues, Natural surfaces, Monte Carlo methods, Glasses, Fiber optics, Index matching antireflective coatings, Signal detection

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Proceedings Article | 23 March 2005 Paper

Depth-sensitive reflectance measurements using obliquely oriented fiber probes

Adrien Wang, Janelle Bender, T. Pfefer, Urs. Utzinger, Rebekah Drezek

Proceedings Volume 5691, (2005) https://doi.org/10.1117/12.593655

KEYWORDS: Reflectivity, Tissue optics, Photons, Tissues, Natural surfaces, Monte Carlo methods, Fiber optics, Glasses, Signal detection, Index matching antireflective coatings

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Showing 5 of 7 publications

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