Dr. Joel N. Bixler Profile

Dr. Joel N. Bixler

Scientist

SPIE Involvement:

Conference Chair | Author | Editor

Publications (39)

Proceedings Article | 10 June 2024 Presentation

Elucidating biophysical mechanisms of directed energy exposure using quantitative phase imaging

Zachary Steelman, Sean O'Connor, Anna Sedelnikova, Matthew Conway, Stacey Martens, Joel Bixler

Proceedings Volume PC13041, PC1304107 (2024) https://doi.org/10.1117/12.3012964

KEYWORDS: Phase imaging, Directed energy weapons, Water, Biological imaging, Water content, Viscosity, Refractive index, Biomedical optics, Video, Spherical lenses

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Proceedings Article | 10 April 2024 Presentation

Double integrating sphere optical properties measurements of thermally-damaged porcine dermis

Anjelyka Fasci, Mark Keppler, Andrea Smith, Matthew Macasadia, Amanda Tijerina, R. Lyle Hood, Michael DeLisi, Joel Bixler

Proceedings Volume PC12840, PC128400E (2024) https://doi.org/10.1117/12.3000199

KEYWORDS: Optical properties, Tissues, Integrating spheres, Biological samples, Tissue optics, Laser tissue interaction, Biomedical optics, Temperature metrology, Skin, Simulations

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Proceedings Article | 13 March 2024 Presentation

Elucidating biophysical mechanisms using quantitative phase imaging to track transmembrane water flux in living cells

Sean O'Connor, Anna Sedelnikova, Matthew Conway, Stacey Martens, Allen Kiester, Joel Bixler, Zachary Steelman

Proceedings Volume PC12852, PC128520O (2024) https://doi.org/10.1117/12.2688768

KEYWORDS: Phase imaging, Water content, Video, Spherical lenses, Proteins, Phase shifts, Mercury, Glia, Electric fields

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Proceedings Article | 13 March 2024 Presentation

Visualization of cellular membrane charging induced by MHz compressed trains of nanosecond pulsed electric fields

Mark Keppler, Ines Abrahamsson, Gleb Tolstykh, Benjamin Kasukonis, Vladislav Yakovlev, Joel Bixler

Proceedings Volume PC12840, PC1284002 (2024) https://doi.org/10.1117/12.3021425

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Proceedings Article | 13 March 2024 Presentation

Varying laser pulse widths influence infrared neural stimulation efficacy in vitro

Jacob Hardenburger, Bryan Gamboa, Joel Bixler, Christopher Valdez, Bryan Millis, E. Duco Jansen, Anita Mahadevan-Jansen

Proceedings Volume 12829, 1282905 (2024) https://doi.org/10.1117/12.3004830

KEYWORDS: In vitro testing, Infrared radiation, Pulsed laser operation, Pulse signals, Neurons, Calcium, Infrared imaging, Optical fibers, Nervous system, Microscopes

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Proceedings Article | 4 October 2023 Presentation

3D imaging of pulsed laser ablation at 1 million frames per second using a rotary mirror and strobe photography

Joel Bixler

Proceedings Volume 12693, 126931E (2023) https://doi.org/10.1117/12.2679007

KEYWORDS: Laser ablation, Photography, Mirrors, Stereoscopy, Tissues, Biological imaging, Ultrafast imaging, Light sources and illumination, Imaging systems, Image sensors

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SPIE Journal Paper | 30 June 2023 Open Access

Comparing the segmentation of quantitative phase images of neurons using convolutional neural networks trained on simulated and augmented imagery

Eddie Gil, Zachary Steelman, Anna Sedelnikova, Joel Bixler

NPh, Vol. 10, Issue 03, 035004, (June 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.3.035004

KEYWORDS: Image segmentation, Education and training, Neurons, Data modeling, Performance modeling, Neurophotonics, Tunable filters, Statistical modeling, Image processing, Convolutional neural networks

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Proceedings Article | 16 March 2023 Presentation + Paper

Deep learning-based neuron segmentation in quantitative phase images trained on procedurally generated data

Eddie Gil, Anna Sedelnikova, Zachary Steelman, Joel Bixler

Proceedings Volume 12389, 1238903 (2023) https://doi.org/10.1117/12.2650212

KEYWORDS: Image segmentation, Education and training, Neurons, Data modeling, Gallium nitride, Statistical modeling, Background noise, Performance modeling, Microscopes, Network architectures

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Proceedings Article | 16 March 2023 Presentation

Dynamic tracking of water influx and efflux across cellular membranes using quantitative phase imaging (Conference Presentation)

Zachary Steelman, Stacey Martens, Jennifer Tran, Anna Sedelnikova, Allen Kiester, Bennett Ibey, Joel Bixler

Proceedings Volume PC12391, PC123910D (2023) https://doi.org/10.1117/12.2647560

KEYWORDS: Phase imaging, Spherical lenses, Plasma, Organisms, Diffusion, Biophysics, Biology

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Proceedings Article | 7 March 2023 Presentation

Estimations of ablation kinetics using rotary mirror strobe photography at 1 million frames per second

Joel Bixler, Allen Kiester

Proceedings Volume PC12377, PC1237706 (2023) https://doi.org/10.1117/12.2656967

KEYWORDS: Laser ablation, Visualization, Photography, Ultrafast phenomena, Ultrafast lasers, Ultrafast imaging, Sensors, Pulsed laser operation, Pixel resolution, Laser tissue interaction

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Proceedings Article | 7 March 2023 Presentation + Paper

The effects of cold storage on double integrating sphere optical properties measurements of porcine skin and subcutaneous fat

Priscilla Lopez, Mark Keppler, Matthew Macasadia, Andrea Smith, Amanda Tijerina, R. Lyle Hood, Michael DeLisi, Joel Bixler

Proceedings Volume 12377, 1237705 (2023) https://doi.org/10.1117/12.2650502

KEYWORDS: Tissues, Biological samples, Absorption, Optical properties, Reflectivity, Scattering, Optical spheres, Integrating spheres, Skin, Transmittance

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Proceedings Article | 2 March 2022 Paper

Optical properties of porcine skin and subcutaneous tissue following various methods of cold storage

Michael DeLisi, Amanda Peterson, Amanda Tijerina, Matthew Macasadia, Zachary Coker, R. Lyle Hood, Joel Bixler

Proceedings Volume 11958, 1195803 (2022) https://doi.org/10.1117/12.2611109

KEYWORDS: Optical properties, Tissues, Tissue optics, Skin, Absorption, Scattering, Optical testing, Transmittance, Reflectivity, Sensors

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Proceedings Article | 2 March 2022 Presentation + Paper

Segmenting quantitative phase images of neurons using a deep learning model trained on images generated from a neuronal growth model

Eddie Gil, Zachary Steelman, Anna Sedelnikova, Joel Bixler

Proceedings Volume 11970, 1197007 (2022) https://doi.org/10.1117/12.2608770

KEYWORDS: Image segmentation, Neurons, Data modeling, Phase imaging, Neural networks, Gallium nitride, Network architectures, Data acquisition, Convolution, Machine learning

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Proceedings Article | 2 March 2022 Poster

Quantitative phase microscopy monitors cellular water content and other biophysical parameters during electroporation

Zachary Steelman, Zachary Coker, Stacey Martens, Anna Sedelnikova, Allen Kiester, Bennett Ibey, Joel Bixler

Proceedings Volume PC11970, PC119700L (2022) https://doi.org/10.1117/12.2606897

KEYWORDS: Microscopy, Directed energy weapons, Visualization, Refractive index, Proteins, Phase imaging, Coherence imaging, Atomic force microscopy

Proceedings Article | 2 March 2022 Poster

Simultaneous quantitative phase imaging and Brillouin spectroscopy determine cell longitudinal modulus

Zachary Coker, Zachary Steelman, Joel Bixler

Proceedings Volume PC11970, PC119700Q (2022) https://doi.org/10.1117/12.2608890

KEYWORDS: Microscopy, Phase imaging, Spectroscopy, Refractive index, Imaging spectroscopy

Proceedings Article | 2 March 2022 Presentation

Dynamic nitrogen vacancy magnetometry via compressed single-shot imaging

Mark Keppler, Philip Hemmer, Vladislav Yakovlev, Joel Bixler

Proceedings Volume PC11971, PC1197109 (2022) https://doi.org/10.1117/12.2612170

KEYWORDS: Nitrogen, Magnetism, Magnetic sensors, Sensors, Diamond, Zeeman effect, Temporal resolution, Spatial resolution, Photons, Photomultipliers

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Proceedings Article | 7 February 2022 Presentation

Quantitative phase microscopy monitors biophysical properties of cells undergoing pulsed electric field exposure

Zachary Steelman, Zachary Coker, Stacey Martens, Jennifer Tran, Anna Sedelnikova, Allen Kiester, Bennett Ibey, Joel Bixler

Proceedings Volume PC11958, PC119580A (2022) https://doi.org/10.1117/12.2606465

KEYWORDS: Microscopy, Proteins, Phase imaging, Coherence imaging

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Proceedings Article | 5 March 2021 Presentation

Assessing membrane charging by alternating electric fields in giant unilamellar vesicles

Allen Kiester, Stacey Martens, Zachary Coker, Mara Casebeer, Joel Bixler, Esin Sözer, Bennett Ibey

Proceedings Volume 11640, 1164009 (2021) https://doi.org/10.1117/12.2578299

KEYWORDS: Streak cameras, Particle filters, Microscopy, Visualization, Picosecond phenomena, Optogenetics, Neurophotonics, Luminescence, Cameras

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Proceedings Article | 5 March 2021 Presentation

Seeing the trees through the forest: training generalizable denoising neural networks using simulated data

Eddie Gil, Zachary Coker, Vsevolod Cheburkanov, Joel Bixler, Vladislav Yakovlev

Proceedings Volume 11622, 1162204 (2021) https://doi.org/10.1117/12.2582380

KEYWORDS: Neural networks, Denoising, Signal processing, Signal detection, Raman spectroscopy, Inverse problems, Inverse optics, Interference (communication), Image segmentation, Image processing

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Proceedings Article | 5 March 2021 Presentation

Brillouin imaging for noncontact and label-free 2D and 3D mapping of cellular mechanical properties

Maria Troyanova-Wood, Zachary Coker, Joel Bixler, Bennett Ibey

Proceedings Volume 11655, 116551F (2021) https://doi.org/10.1117/12.2578835

KEYWORDS: 3D image processing, Tissues, Imaging systems, Stereoscopy, Spatial resolution, Molecules, Image filtering, Elastography, Atomic force microscopy

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Proceedings Article | 10 March 2020 Presentation

Visualization of membrane potential changes induced by oscillating electric fields (Conference Presentation)

Allen Kiester, Zach Coker, Bennett Ibey, Joel Bixler

Proceedings Volume 11250, 112500O (2020) https://doi.org/10.1117/12.2546029

KEYWORDS: Visualization, Plasma, Imaging systems, Streak cameras, Microscopes, Particle filters, Dielectrics

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Proceedings Article | 9 March 2020 Presentation

Machine learning estimations of tissue optical properties for a multi-layered model (Conference Presentation)

Joel Bixler, Brett Hokr

Proceedings Volume 11238, 112380Q (2020) https://doi.org/10.1117/12.2546816

KEYWORDS: Optical properties, Tissue optics, Machine learning, Monte Carlo methods, Tissues, Neural networks, Laser tissue interaction, In vivo imaging, Optical testing, Absorption

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Proceedings Article | 9 March 2020 Presentation

Prediction of tissue optical properties using Monte Carlo modeling of photon transport in turbid media and integrating spheres (Conference Presentation)

Patrick Cook, Joel Bixler, Robert Thomas, Edward Early

Proceedings Volume 11238, 112380P (2020) https://doi.org/10.1117/12.2542548

KEYWORDS: Monte Carlo methods, Photon transport, Tissue optics, Integrating spheres, Optical properties, Optical spheres, Reflectivity, Transmittance, Laser tissue interaction

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Proceedings Article | 20 February 2020 Presentation + Paper

Neural network generation for estimation of tissue optical properties

Eddie Gil, Brett Hokr, Joel Bixler

Proceedings Volume 11238, 1123809 (2020) https://doi.org/10.1117/12.2546068

KEYWORDS: Monte Carlo methods, Optical properties, Neural networks, Backscatter, Convolution, Tissue optics, Photon transport, Scattering, Tissues, Matrices, Machine learning

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Proceedings Article | 20 February 2020 Paper

Compressed hyperspectral Raman microscope for imaging tissues and cellular structures

Mark Keppler, Eddie Gil, Sean O'Connor, Gary Noojin, Vladislav Yakovlev, Joel Bixler

Proceedings Volume 11238, 112380N (2020) https://doi.org/10.1117/12.2544571

KEYWORDS: Raman spectroscopy, Digital micromirror devices, Microscopes, Spectroscopy, Defense and security, Hyperspectral imaging, Diffraction gratings, Diffraction

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Proceedings Article | 30 December 2019 Paper

Applications for compressed ultrafast photography to biological imaging and sensing

Joel Bixler, Allen Keister, Zach Coker, Bennett Ibey

Proceedings Volume 11202, 1120204 (2019) https://doi.org/10.1117/12.2540049

KEYWORDS: Ultrafast imaging, Photography, Streak cameras, Biosensing, Hyperspectral imaging, Argon ion lasers, Imaging systems, Luminescence, Microscopy, Imaging spectroscopy

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Proceedings Article | 4 March 2019 Paper

Evaluation of membrane potential changes induced by unipolar and bipolar nanosecond pulsed electric fields

Bennett Ibey, Joel Bixler, Caleb Roth, Hope Beier

Proceedings Volume 10889, 1088913 (2019) https://doi.org/10.1117/12.2511189

KEYWORDS: Plasma, Streak cameras, Calcium, Microscopes, Luminescence, Microscopy, Electrodes, Cameras

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Proceedings Article | 1 March 2019 Paper

Comparison of various neural network-based models for retinal lesion analysis

Eddie Gil, Mark Keppler, Vladislav Yakovlev, Adam Boretsky, Joel Bixler

Proceedings Volume 10876, 108760M (2019) https://doi.org/10.1117/12.2507908

KEYWORDS: Image filtering, Image segmentation, Network architectures, Linear filtering, Convolution, Convolutional neural networks, Macula

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Proceedings Article | 1 March 2019 Presentation + Paper

Comparison of various neural network-based models for retinal lesion analysis

Eddie Gil, Mark Keppler, Vladislav Yakovlev, Adam Boretsky, Joel Bixler

Proceedings Volume 10876, 108760V (2019) https://doi.org/10.1117/12.2510006

KEYWORDS: Image filtering, Image segmentation, Network architectures, Convolution, Linear filtering, Optical filters, Macula, Neural networks, Performance modeling, Convolutional neural networks

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Proceedings Article | 22 February 2017 Presentation + Paper

High speed fluorescence imaging with compressed ultrafast photography

J. Thompson, J. Mason, H. Beier, J. Bixler

Proceedings Volume 10076, 1007613 (2017) https://doi.org/10.1117/12.2251025

KEYWORDS: Microscopes, Digital micromirror devices, Fluorescence lifetime imaging, Image compression, Binary data, Ultrafast imaging, Photography, Compressed sensing, High speed photography, Microscopy, Streak cameras, Temporal resolution, Luminescence, Optical imaging, Temperature metrology

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Proceedings Article | 9 March 2016 Paper

Lighting up microscopy with random Raman lasing

Brett Hokr, Dawson Nodurft, Jonathan Thompson, Joel Bixler, Gary Noojin, Brandon Redding, Robert Thomas, Hui Cao, Benjamin Rockwell, Marlan Scully, Vladislav Yakovlev

Proceedings Volume 9732, 973208 (2016) https://doi.org/10.1117/12.2212886

KEYWORDS: Raman spectroscopy, Microscopy, Light sources, Spatial coherence, Laser spectroscopy, Light sources and illumination, Microscopes, Mercury, Lamps, Temporal resolution, Speckle, Laser induced damage, Charge-coupled devices, Laser scattering

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Proceedings Article | 7 March 2016 Presentation + Paper

Accurately modeling Gaussian beam propagation in the context of Monte Carlo techniques

Brett Hokr, Aidan Winblad, Joel Bixler, Gabriel Elpers, Byron Zollars, Marlan Scully, Vladislav Yakovlev, Robert Thomas

Proceedings Volume 9706, 970614 (2016) https://doi.org/10.1117/12.2213653

KEYWORDS: Monte Carlo methods, Photons, Diffraction, Optical simulations, Gaussian optics, Laser tissue interaction, Gaussian beams, Beam propagation method, Microscopy, Tissue optics, Tissues, Natural surfaces, Scattering, Absorption, Laser scattering

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Proceedings Article | 7 March 2016 Presentation + Paper

Methods for variance reduction in Monte Carlo simulations

Joel Bixler, Brett Hokr, Aidan Winblad, Gabriel Elpers, Byron Zollars, Robert Thomas

Proceedings Volume 9706, 970612 (2016) https://doi.org/10.1117/12.2213470

KEYWORDS: Monte Carlo methods, Diffraction, Photons, Gaussian optics, Geometrical optics, Computer simulations, Chemical analysis, Gold, Ranging, Multiphoton fluorescence microscopy, Scattering, Error analysis, Statistical analysis, Tissue optics, Ray tracing, Scattering media

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Proceedings Article | 4 March 2016 Paper

Evidence of Anderson localization effects in random Raman lasing

Brett Hokr, Alexander Cerjan, Jonathan Thompson, Luqi Yuan, Seng Fatt Liew, Joel Bixler, Gary Noojin, Robert Thomas, Hui Cao, A. Douglas Stone, Benjamin Rockwell, Marlan Scully, Vladislav Yakovlev

Proceedings Volume 9731, 973110 (2016) https://doi.org/10.1117/12.2212911

KEYWORDS: Raman spectroscopy, Diffusion, Absorption, Raman scattering, Monte Carlo methods, Photons, Picosecond phenomena, Statistical modeling, Nonlinear dynamics, Nonlinear optics, Speckle, Laser applications, Charge-coupled devices, Wave propagation, Laser scattering

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Proceedings Article | 12 March 2015 Paper

Low cost integrating cavity for monitoring of environmental toxins

Joel Bixler, Chase Winkler, John Mason, Vladislav Yakovlev

Proceedings Volume 9314, 93140T (2015) https://doi.org/10.1117/12.2079958

KEYWORDS: Chemical analysis, Statistical analysis, Raman spectroscopy, Contamination, Luminescence, Environmental monitoring, Liquids, Reflectivity, Spectroscopy, Pathogens

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Proceedings Article | 5 March 2015 Paper

Modeling of tissue heating under tunable near IR radiation

Joel Bixler, Brett Hokr, Chad Oian, Aaron Hoffman, Vladislav Yakovlev, Robert Thomas

Proceedings Volume 9321, 93210D (2015) https://doi.org/10.1117/12.2079979

KEYWORDS: Tissues, Tissue optics, Laser tissue interaction, Radiation effects, Laser damage threshold, Thermal modeling, Infrared radiation, Near infrared, Optical parametric oscillators, Thermography

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SPIE Journal Paper | 9 July 2014 Open Access

Assessment of tissue heating under tunable near-infrared radiation

Joel Bixler, Brett Hokr, Michael Denton, Gary Noojin, Aurora Shingledecker, Hope Beier, Robert Thomas, Benjamin Rockwell, Vladislav Yakovlev

JBO, Vol. 19, Issue 07, 070501, (July 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.7.070501

KEYWORDS: Tissues, Tissue optics, Thermography, Laser tissue interaction, Laser damage threshold, Temperature metrology, Radiation effects, Optical parametric oscillators, Imaging systems, Cameras

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Proceedings Article | 4 March 2014 Paper

A new SERS: scattering enhanced Raman scattering

Joel Bixler, Vladislav Yakovlev

Proceedings Volume 8939, 893909 (2014) https://doi.org/10.1117/12.2040803

KEYWORDS: Raman spectroscopy, Raman scattering, Reflectivity, Scattering, Surface enhanced Raman spectroscopy, Light scattering, Quartz, Laser scattering, Liquids, Gases

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Proceedings Article | 8 March 2013 Paper

Multi-scale fluorescence imaging of bacterial infections in animal models

Joel Bixler, Ying Kong, Jeffrey Cirillo, Kristen Maitland

Proceedings Volume 8565, 856537 (2013) https://doi.org/10.1117/12.2004690

KEYWORDS: Luminescence, Imaging systems, Lung, Signal detection, In vivo imaging, Tissues, Animal model studies, Bacteria, Light emitting diodes, CCD cameras

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