Dr. Jonathan Gan Profile

Dr. Jonathan Gan

at Imperial College London

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Publications (3)

Proceedings Article | 13 March 2024 Presentation + Paper

A wireless semi-wearable sensor for assessment of gut function in low-resource settings

Nilanjan Mandal, Elena Monfort Sanchez, James Avery, Jonathan Gan, Qian Chen, Mulima Mwiinga, Rose Banda, Paul Kelly, Alex Thompson

Proceedings Volume 12832, 1283206 (2024) https://doi.org/10.1117/12.3002394

KEYWORDS: Sensors, Fluorescence, Permeability, Fiber optics, Contrast agents

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SPIE Journal Paper | 28 February 2024 Open Access

Transcutaneous fluorescence spectroscopy: development and characterization of a compact, portable, and fiber-optic sensor

Elena Monfort Sanchez, James Avery, Jonathan Gan, Jingjing Qian, Nilanjan Mandal, Arjun Agarwal, Mulima Mwiinga, Rose Banda, Ara Darzi, Paul Kelly, Alex Thompson

JBO, Vol. 29, Issue 02, 027003, (February 2024) https://doi.org/10.1117/12.10.1117/1.JBO.29.2.027003

KEYWORDS: Fluorescence, Sensors, Fluorescence intensity, Photodiodes, Fluorescence spectroscopy, Skin, Magnesium, Light emitting diodes, Permeability, Contrast agents

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SignificanceThe integrity of the intestinal barrier is gaining recognition as a significant contributor to various pathophysiological conditions, including inflammatory bowel disease, celiac disease, environmental enteric dysfunction (EED), and malnutrition. EED, for example, manifests as complex structural and functional changes in the small intestine leading to increased intestinal permeability, inflammation, and reduced absorption of nutrients. Despite the importance of gut function, current techniques to assess intestinal permeability (such as endoscopic biopsies or dual sugar assays) are either highly invasive, unreliable, and/or difficult to perform in certain patient populations (e.g., infants).AimWe present a portable, optical sensor based on transcutaneous fluorescence spectroscopy to assess gut function (in particular, intestinal permeability) in a fast and noninvasive manner.ApproachParticipants receive an oral dose of a fluorescent contrast agent, and a wearable fiber-optic probe detects the permeation of the contrast agent from the gut into the blood stream by measuring the fluorescence intensity noninvasively at the fingertip. We characterized the performance of our compact optical sensor by comparing it against an existing benchtop spectroscopic system. In addition, we report results from a human study in healthy volunteers investigating the impact of skin tone and contrast agent dose on transcutaneous fluorescence signals.ResultsThe first study with eight healthy participants showed good correlation between our compact sensor and the existing benchtop spectroscopic system [correlation coefficient (r)>0.919, p<0.001]. Further experiments in 14 healthy participants revealed an approximately linear relationship between the ingested contrast agent dose and the collected signal intensity. Finally, a parallel study on the impact of different skin tones showed no significant differences in signal levels between participants with different skin tones (p>0.05).ConclusionsIn this paper, we demonstrate the potential of our compact transcutaneous fluorescence sensor for noninvasive monitoring of intestinal health.

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Proceedings Article | 6 March 2023 Presentation + Paper

A compact fluorescence sensor for low-cost non-invasive monitoring of gut permeability in undernutrition

Elena Monfort Sánchez, James Avery, Jonathan Gan, Jingjing Qian, Mulima Mwiinga, Rosemary Banda, Jonathan Hoare, Hutan Ashranfian, Ara Darzi, Paul Kelly, Alex Thompson

Proceedings Volume 12369, 1236904 (2023) https://doi.org/10.1117/12.2649030

KEYWORDS: Fluorescence, Sensors, Permeability, Signal detection, Fluorescence spectroscopy, Contrast agents, Medical research, Light emitting diodes, Parkinson disease

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