Mr. Kazuma Shiotani Profile

Kazuma Shiotani

at Kyoto Univ

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Publications (2)

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Proceedings Article | 5 March 2021 Poster + Presentation + Paper

Detecting and evaluating vulnerable artery plaque with handheld photoacoustic imaging system

Kazuma Shiotani, Takeshi Namita, Kengo Kondo, Makoto Yamakawa, Tsuyoshi Shiina

Proceedings Volume 11642, 1164241 (2021) https://doi.org/10.1117/12.2577632

KEYWORDS: Photoacoustic spectroscopy, Tissue optics, Silicon, Absorption, Arteries, Imaging systems, Photoacoustic imaging, Ultrasonography, Tissues, Blood

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Aortic atherosclerotic plaque rupture can cause cerebral and cardiac infarction. Detecting lipid-rich vulnerable plaque early is important to prevent plaque rupture. However, using conventional modalities to evaluate such plaques is difficult. Photoacoustic imaging can elucidate tissue characteristics. Some lipid-rich plaque evaluations have used intravascular photoacoustic imaging systems. A handheld photoacoustic imaging system was developed to reduce invasiveness and to ease handling. Lipid-rich plaque detection capability was evaluated using phantom experiments. Mimic plaques (comprising oleic acid cholesterol and linoleic acid cholesterol) are embedded into a silicone tube. The silicone tube is filled with ovine blood. These objects were fixed in a water with black ink and biological tissue (chicken breast). For observation, laser light is guided to the model phantom surface by an optical fiber bundle close to the linear ultrasound probe. The photoacoustic signal distributions are then recorded as photoacoustic images. The photoacoustic images, obtained for which wavelengths where lipid light absorbance is high, show strong photoacoustic signals from the mimic plaque at a depth of human carotid artery. At wavelengths of 1150–1300 nm, similarity between photoacoustic spectra and the absorption spectrum of lipid was evaluated by calculating the correlation coefficient in photoacoustic images. Results show high correlation at the mimic plaque. Results demonstrate that the detection of lipid-rich plaque can be done, even optical properties (e.g. scattering coefficient and absorption coefficient) of the surrounding tissue were inhomogeneous. Future studies must conduct in vivo experiments and examine optimization to improve SNR.

Proceedings Article | 17 February 2020 Paper

Detecting and evaluating lipid-lich artery plaque using a handheld photoacoustic imaging system

Kazuma Shiotani, Takeshi Namita, Kengo Kondo, Makoto Yamakawa, Tsuyoshi Shiina

Proceedings Volume 11240, 1124052 (2020) https://doi.org/10.1117/12.2545622

KEYWORDS: Photoacoustic spectroscopy, Silicon, Photoacoustic imaging, Absorption, Arteries, Imaging systems, Aorta, Ultrasonography, Scattering, Tissue optics

Read Abstract +

Early detection of lipid-rich vulnerable plaque is important to prevent aortic atherosclerotic plaque rupture, which can cause cerebral and cardiac infarction. Nevertheless, evaluating such plaques using conventional modalities is difficult. Photoacoustic imaging can reveal and clarify tissue characteristics. Some evaluations of lipid-rich plaque have used intravascular photoacoustic imaging systems. To reduce invasiveness and to ease handling, we developed a handheld photoacoustic imaging system. The possibility of detecting lipid-rich plaques was evaluated in phantom experiments. A plaque was modeled using a mimic plaque (a mix of oleic acid cholesterol and linoleic acid cholesterol) into an ovine aortic wall and silicone tube. The ovine aorta and the silicone tube were then filled with ovine blood. These objectives were fixed in pellucid deaerated water or in deaerated water including intralipid suspension. Laser light was guided to the model phantom surface by an optical fiber bundle close to the linear ultrasound probe. The photoacoustic signal distribution was measured as photoacoustic images. The photoacoustic images, taken using wavelengths at which light absorbance of lipid is high, show strong photoacoustic signals from the fat boundary. At 1150–1300 nm wavelengths, similarity between photoacoustic spectra and the absorption spectrum of lipid were evaluated by calculating the correlation coefficient in photoacoustic images. Results show high correlation (more than 0.9) at the boundary between the fat and the vessel wall. These analyses demonstrate detection of lipid-rich plaque even if a highly absorbing object, e.g. blood, is in proximity to the lipid.

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