Cerebral autoregulation (CA), the brain’s ability to regulate perfusion independently of blood pressure, can be assessed by evaluating the degree of correlation between cerebral blood flow (CBF) and mean arterial pressure. Non-invasive, optical measurements of brain hemodynamics using DCS/NIRS can be used to assess CA and show agreement with invasive metrics (laser doppler perfusion and intracranial pressure) in a pediatric swine model of cardiac arrest. Wavelet based coherence methods of assessing autoregulation are a useful alternative to correlation based methods.
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